Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. Phospho-SGK223 (Y413) Antibody

Phospho-SGK223 (Y413) Antibody

  • 货号：
    CSB-PA007578
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using Phospho-Pragmin (Y413) Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q86YV5
  • 基因名：
    PRAG1
  • 别名：
    D8Ertd82e antibody; DKFZp761P0423 antibody; DNA segment, Chr 8, ERATO Doi 82 antibody; EC 2.7.10.2 antibody; Homolog of rat pragma of Rnd2 antibody; LOC157285 antibody; PRAGMIN antibody; SG223_HUMAN antibody; Sgk223 antibody; Sugen kinase 223 antibody; Tyrosine protein kinase SgK223 antibody; Tyrosine-protein kinase SgK223 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human Pragmin around the phosphorylation site of Y413.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth. Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism. Acts as a critical coactivator of Notch signaling.
  • 基因功能参考文献：
    1. analysis of how the kinase fold mediates non-catalytic functions in SgK223 PMID: 29079850
    2. deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis PMID: 27116701
    3. Results provide evidence that NACK was strongly expressed in a subset of non-small cell lung cancer (NSCLCL) samples and interference of NACK inhibits NSCLC progression through failing to activate Notch1 signaling complexes. PMID: 26782286
    4. Increased expression of SgK223 occurs in PDAC, and overexpression of SgK223 in pancreatic ductal epithelial cells promotes acquisition of a migratory and invasive phenotype through enhanced JAK1/Stat3 signaling PMID: 26215634
    5. Pragmin as a mammalian EPIYA effector and suggests that bacterial EPIYA effectors target Pragmin to subvert SFKs for successful infection. PMID: 21873224
    6. Rnd2 regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to Rnd1 and Rnd3 inhibiting RhoA signaling PMID: 16481321
    7. Also known as SgK223, a member of the NKF3 subfamily of eukaryotic protein kinases. PMID: 12471243

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Cell junction, focal adhesion. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily
  • 数据库链接：

    HGNC: 25438

    OMIM: 617344

    KEGG: hsa:157285

    STRING: 9606.ENSP00000330930

    UniGene: Hs.583863