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  4. Phospho-RRN3 (S649) Antibody

Phospho-RRN3 (S649) Antibody

  • 货号：
    CSB-PA030142
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9NYV6
  • 基因名：
    RRN3
  • 别名：
    AL023001 antibody; DKFZp566E104 antibody; E130302O19Rik antibody; MGC104238 antibody; R75565 antibody; RGD1305001 antibody; RNA polymerase I-specific transcription initiation factor RRN3 antibody; Rrn3 antibody; RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) antibody; RRN3_HUMAN antibody; TIF-IA antibody; TIF1A antibody; TIFIA antibody; Transcription Initiation Factor 1A antibody; Transcription initiation factor IA antibody; Transcription initiation factor TIF IA antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from Human Rrn3 around the phosphorylation site of S649.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction.
  • 基因功能参考文献：
    1. These data support a model in which activated Akt enhances rRNA synthesis both by preventing TIF-IA degradation and phosphorylating CK2alpha, which in turn phosphorylates TIF-IA. PMID: 24297901
    2. DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription PMID: 23393135
    3. reveals the molecular basis of Rrn3-regulated Pol I initiation and cell growth PMID: 21940764
    4. Data show that nutrient starvation, density arrest and protein synthesis inhibitors inactivate transcription initiation factor-IA and impair its association with RNA polymerase I. PMID: 12393749
    5. ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. PMID: 12620228
    6. Phosphorylation of S44 activates and S199 inactivates TIF-IA. PMID: 15004009
    7. The definition of the Alu element within the TIF-IA gene as an exon is restricted to certain types of cancers; the element is not exonized in normal human cells. PMID: 18047649
    8. CK2 phosphorylates the transcription initiation factor TIF-IA at serines 170 and 172 (Ser170/172), and this phosphorylation triggers the release of TIF-IA from Pol I after transcription initiation. PMID: 18559419

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  • 亚细胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    RRN3 family
  • 数据库链接：

    HGNC: 30346

    OMIM: 605121

    KEGG: hsa:54700

    STRING: 9606.ENSP00000198767

    UniGene: Hs.460078