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  4. Phospho-PRKG2 (S126) Antibody

Phospho-PRKG2 (S126) Antibody

  • 货号：
    CSB-PA030288
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q13237
  • 基因名：
  • 别名：
    CGK 2 antibody; cGK2 antibody; cGKII antibody; cGMP dependent protein kinase 2 antibody; cGMP-dependent protein kinase 2 antibody; cGMP-dependent protein kinase II antibody; KGP2_HUMAN antibody; PRKG 2 antibody; PRKG2 antibody; PRKGR2 antibody; Protein kinase; cGMP dependent; type II antibody; Type II cGMP dependent protein kinase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human cGKII around the phosphorylation site of S126.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation.
  • 基因功能参考文献：
    1. L-Arginine is a potential alternative to PKG II activation. PMID: 29401205
    2. Comparative analysis of the backbone hydrogen/deuterium exchange patterns in PKG II:8-pCPT-cGMP and previously reported PKG Ibeta:cGMP XN structures suggests that the ability of these agonists to activate PKG is related to how effectively they quench dynamics of the cyclic nucleotide binding pocket and the surrounding regions. PMID: 29517905
    3. the results indicated that PKG II could block c-Met activation via phosphorylating Ser985 PMID: 27147579
    4. PKG II inhibits EGFinduced activation of HER2 through binding with and causing threonine 686 phosphorylation of this oncogenic protein. PMID: 26676300
    5. The C-terminal cyclic nucleotide binding (CNB-B) domain of cGMP-dependent protein kinase II binds cGMP with higher affinity and selectivity when compared with its N-terminal CNB (CNB-A) domain. PMID: 26769964
    6. Han Chinese patients with rs10033237 polymorphism of cGKII/PRKG2 gene are more likely to suffer from gout. PMID: 25688884
    7. Our replication study suggests that cGKII is not involved in gout susceptibility. PMID: 24882840
    8. we determined a crystal structure of the PKG II LZ-Rab11b complex. The PKG II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van der Waals interactions PMID: 25070890
    9. PKGII inhibits RhoA activity by binding to this small GTPase and causing phosphorylation at its Ser188 site. PMID: 24549567
    10. PKG II also inhibits the activation of the EGFR caused by diverse ligands of the receptor. PMID: 24534906
    11. type II cGMPdependent protein kinase prevented the EGF-induced phosphorylation/activation of ERK and JNK, but not the phosphorylation of p38MAPK induced by EGF. PMID: 22940826
    12. Downregulation of PKG2 was associated with malignant and benign breast tumors. PMID: 22791569
    13. The work presented here demonstrates a novel antiproliferative and prodifferentiation role for PKG2 in the colon. PMID: 22556146
    14. The results suggest that PKGII inhibits EGF-induced MAPK/JNK-mediated signal transduction and further confirmed that PKGII can block the activation of EGFR. PMID: 22427012
    15. PKG II inhibits the proliferation of gastric cancer cells through blocking EGF-triggered MAPK signal transduction. PMID: 22012247
    16. As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype. PMID: 22303795
    17. Inhibition of cGMP-dependent protein kinase II by its own splice isoform PMID: 12054676
    18. results show that the fast phase of autophosphorylation of cGMP dependent protein kinase II has a small effect on its activity, whereas the secondary phase involving Ser126 phosphorylation may generate an active form PMID: 12764134
    19. Characterization of the 4q21 breakpoint revealed PRKG2 as the likely gene partner to PDGFRB in myeloproliferative disorders. PMID: 18262053
    20. Results suggest that the cGK II gene on chromosome 4q21 is most likely to harbour gout disease independently of hyperuricaemia and is inherited recessively. PMID: 18678579
    21. Regulation of epithelial sodium channels by cGMP/PKGII. PMID: 19359370
    22. PRKG2 inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines. PMID: 19543319

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  • 亚细胞定位：
    Apical cell membrane; Lipid-anchor.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, cGMP subfamily
  • 组织特异性：
    Highly concentrated in brain, lung and intestinal mucosa.
  • 数据库链接：

    HGNC: 9416

    OMIM: 601591

    KEGG: hsa:5593

    STRING: 9606.ENSP00000264399

    UniGene: Hs.232044