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  4. Phospho-PGR (Ser190) Antibody

Phospho-PGR (Ser190) Antibody

  • 货号：
    CSB-PA697709
  • 规格：
    ￥2454
  • 图片：
    • Western blot analysis of extracts from SKOV3 cells untreated(lane 1) or treated with EGF(lane 2) using Progesterone Receptor(Phospho-Ser190) Antibody.
    • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Progesterone Receptor(Phospho-Ser190) Antibody.
    • Immunofluorescence staining of methanol-fixed MCF cells using Progesterone Receptor(Phospho-Ser190) Antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PGR Polyclonal antibody
  • Uniprot No.：
    P06401
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence around phosphorylation site of serine 190 (G-L-S(p)-P-A) derived from Human Progesterone Receptor.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
    IHC 1:50-1:100
    IF 1:100-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.; Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.; Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.; Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
  • 基因功能参考文献：
    1. We found that the Alu insertion was associated with breast cancer incidence in Indians and Indo-European mixed racial groups, but the association disappeared for patients of Caucasian or Latino decent. Our meta-analysis showed that the Alu-insertion progesterone receptor gene polymorphism was not associated with breast cancer. [Meta-analysis] PMID: 29370776
    2. findings showed no association between PROGINS and leiomyoma in the overall analysis nor in either of the subgroups, Asian or non-Asian, in all genetic models;. conclusion: The PROGINS polymorphisms cannot be considered a risk factor for developing uterine leiomyoma - Systematic Review and Meta-Analysis PMID: 29630404
    3. in primary breast tumors, PR-A expression was correlated negatively with miR-92a-3p expression and positively with miR-26b-5p expression. Therefore, hormonal cross-talk of PR-A with ER is probably a fundamental mechanism that enables metastasis of luminal breast cancer. PMID: 29162724
    4. heterogeneous distribution in deep infiltrating endometriosis PMID: 29383962
    5. This study aimed to determine the presence and localization of oestrogen receptors (ERs), progesterone receptors (PRs), and androgen receptors (ARs) in both healthy and varicose vein wall cells and their relationship with gender. PMID: 30250632
    6. These findings suggest that in myometrial cells the repressive activity of PR-A on PR-B increases with advancing gestation and is induced by pro-inflammatory cytokines. PMID: 28671036
    7. polymorphisms do not predict in vitro fertilization outcome PMID: 29916276
    8. Data show that insulin-like growth factor-II mRNA-binding protein 2 and 3 (IMP2/3)-miR-200a-progesterone receptor axis represents a double-negative feedback loop and serves as a new potential therapeutic target for the treatment of Triple-negative breast cancer (TNBC). PMID: 29217458
    9. The experimental data corroborated the inhibitory function of miR-513a-5p on progesterone receptor expression in breast cancer confirming that progesterone receptor is a target of miR-513a-5p PMID: 29126102
    10. A major finding of our study is that one out of five (20%) patients with breast cancer BM had a receptor discrepancy between the primary tumor and the subsequent BM, with loss of hormone receptors (ER and/or PR) expression, and gain of HER2 overexpression as the most commonly observed changes PMID: 28975433
    11. Single nucleotide polymorphism in progesterone receptor gene is associated with the risk of type 2 diabetes among Hispanic Americans compared to European American postmenopausal women. PMID: 29417738
    12. In progesterone control of myometrial contractility during pregnancy and labour, while liganded nuclear progesterone receptor B can suppress the expression of Cx43, unliganded progesterone receptor A paradoxically translocates to the nucleus where it acts as a transcriptional activator of this labour gene. PMID: 27220952
    13. Progesterone receptor, EGFR, and galectin-3 are expressed differentially in uterine smooth muscle tumors. PMID: 29729689
    14. Estrogen receptor (ER) and progesterone receptor (PR) expression in endometrial carcinoma (EC) were significantly higher than those in the paracarcinoma tissue and control. PMID: 29081408
    15. Alcohol consumption may have differential effects on concordant and discordant receptor subtypes of breast cancer. PMID: 29353824
    16. General obesity, indicated by BMI, is more strongly associated with ER+/PR+ subtype, especially among premenopausal women, whereas central obesity, indicated by WHR, is more specific for ER-/PR- subtype, independent of menopausal status. These results suggest that different chemoprevention strategies may be appropriate in selected individuals. PMID: 28912152
    17. TIMP-3 mRNA expression levels positively correlates with levels of miR-21 in in situ breast carcinomas and negatively in progesterone receptor positive invasive breast carcinomas. PMID: 28935174
    18. results suggest differential downstream progesterone receptor signalling, as progesterone receptor regulates MMP3/10 expression via HIF1A, which is not involved in ADAMTS-1 expression PMID: 28736153
    19. Association of progesterone receptor gene polymorphism with threatened abortion. PMID: 29762972
    20. Villin, Pro-Ex-C and progesterone/estrogen receptor expression have diagnostic and predictive roles in endocervical and endometrioid adenocarcinoma. PMID: 28832070
    21. These data collectively indicate that progesterone suppresses triple-negative breast cancer (TNBC) growth and metastasis via mPRalpha, which provides evidence of the anti-neoplastic effects of progesterone-mPRalpha pathway in the treatment of human TNBC. PMID: 28713912
    22. Patients with Estrogen- and progesterone receptors-positive invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC)have similar quantitative ER and PR expression profiles, implicating that ER/PR expression is unlikely to be a confounding factor in studies concerning chemo-sensitivity of ILC and IDC PMID: 28365834
    23. The progesterone receptor B (PRB) and androgen Receptor (AR) mRNA levels were highest in tumors. PMID: 29491078
    24. Chorionic gonadotropin activates Epac-Erk1/Erk2 signaling regulating progesterone receptor expression and function in human endometrial stromal cells. PMID: 28333280
    25. Ten international pathology institutions participated in this study and determined messenger RNA expression levels of ERBB2, ESR1, PGR, and MKI67 in both centrally and locally extracted RNA from formalin-fixed, paraffin-embedded breast cancer specimens with the MammaTyper(R) test. Samples were measured repeatedly on different days within the local laboratories, and reproducibility was assessed by means of variance comp... PMID: 28490348
    26. Human myometrial tissue in culture undergoes changes in progesterone receptor (PR) gene expression consistent with transition toward a laboring phenotype. TSA maintained the nonlaboring PR isoform expression pattern. PMID: 28540297
    27. OHPg/PR-B through Beclin-1 and Bcl2 evoke autophagy-senescence transition in breast cancer cells PMID: 27462784
    28. Report a significant survival benefit in lung adenocarcinoma patients with positive expression of one of the investigated hormonal receptors: androgen receptor, estrogen receptor-alpha or progesterone receptor. PMID: 27690341
    29. We investigate the impact of central histology (n = 772), immunohistochemistry for intrinsic subtyping and IHC4, and dichotomous (GG) or continuous (GGI) genomic grade (n = 472) on patient outcome and benefit from taxane chemotherapy, focusing on HR+/HER2(HR: ER and/or PR)- patients (n = 459) PMID: 27022068
    30. progesterone receptor expression status correlates with final pregnancy outcome PMID: 27728856
    31. RA induced loss of PR binding only at the proximal site. Interestingly, RARalpha was recruited to the -1.1 kb PRE and the -130 bp PRE/RARE regions with P4, but not RA alone or RA plus P4 PMID: 28692043
    32. the 5alpha-reduction of progesterone decreased PR activation significantly, 16alpha-hydroxyprogesterone and 16OH-dihydroprogesterone exhibited comparable receptor activation. PMID: 27664517
    33. C/EBPbeta negatively regulates PR-B expression in glioblastoma cells. PMID: 27663075
    34. Evaluation of progesterone expression in axillary lymph node metastasis of ER-positive, HER2-negative breast cancer may enable prediction of patients who are less likely to benefit from adjuvant tamoxifen. PMID: 28416639
    35. Insight into previously reported associations between +331G/A polymorphism and breast cancer risk. [meta-analysis; review] PMID: 29084518
    36. findings suggest that GATAD2B serves as an important mediator of progesterone-progesterone receptor suppression of proinflammatory and contractile genes during pregnancy; decreased GATAD2B expression near term may contribute to the decline in progesterone receptor function, leading to labor PMID: 28576827
    37. The altered expression of ER and PR may be associated with the expression variation of integrin and pinopode formation in endometrium of luteal phase deficit women. PMID: 27960568
    38. We sought to determine the relation between 17-alpha hydroxyprogesterone caproate plasma concentrations, progesterone receptor single nucleotide polymorphisms and single nucleotide polymorphisms in CYP3A4 and CYP3A5 and spontaneous preterm birth. PMID: 28522317
    39. the estrogen- (ER), progesterone- (PgR) and HER2/neu receptor status of the primary tumor with brain metastases in a series of 24 consecutive breast cancer patients, is reported. PMID: 28870906
    40. we found that combinatorial MK-2206+progesterone treatments decreased angiogenesis and proliferation in the Pten(d/d) conditional mouse model of endometrial cancer. Taken together, these findings suggest that a combinatorial therapeutic approach utilizing Akt inhibitors with progestins may improve the efficacy of progestin therapy for the treatment of endometrial cancer. PMID: 26996671
    41. The interplay between intracellular progesterone receptor and PRKCA-PRKCD plays a key role in migration and invasion of human glioblastoma cells. PMID: 27717886
    42. Folic acid inhibits colon cancer cell proliferation through activation of PR. PMID: 27233474
    43. The endometrial expression of PR and Ki67 along with serum CA125 predicted the development of lymph node metastasis in endometrial cancer. PMID: 27163153
    44. Overexpression of RNA-binding region-containing protein 1 (RNPC1) increased, whereas knockdown of RNPC1 decreased, the level of progesterone receptor (PR) protein and transcripts. PMID: 27634883
    45. analysis of pancreatic adenocarcinoma reveals nPR and the presence of mPR of alpha, beta, gamma subtypes both at the mRNA and protein levels PMID: 27449817
    46. Working model. During most of pregnancy, progesterone via PR-B promotes myometrial cell quiescence in part by repressing responsiveness to proinflammatory stimuli. With advancing gestation, prolabor signals increase the inflammatory load on the uterus until a threshold is reached. The threshold is the point at which inflammatory stimuli augment PR-A stability. PMID: 27886516
    47. Choroidal metastases from BC are associated with ER and PR expression in the primary tumor and the luminal B molecular subtype. PMID: 27479811
    48. Data suggest the relevance of determining the progesterone receptor (PR) isoform ratio before starting antiprogestin treatments. PMID: 28376177
    49. The data show that human parturition involves the phosphorylation of PR-A at serine-345 in myometrial cells and that this process is ligand dependent and induced by a proinflammatory stimulus. PMID: 27653036
    50. PR-B expression was significantly reduced in the eutopic endometrium (p=0.031) and ovarian endometrioma (p=0.036) from women with advanced-stage endometriosis compared with eutopic endometrium tissues from control subjects. PMID: 27593876

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; [Isoform A]: Nucleus. Cytoplasm. Note=Mainly nuclear.; [Isoform 4]: Mitochondrion outer membrane.
  • 蛋白家族：
    Nuclear hormone receptor family, NR3 subfamily
  • 组织特异性：
    In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of th
  • 数据库链接：

    HGNC: 8910

    OMIM: 607311

    KEGG: hsa:5241

    STRING: 9606.ENSP00000325120

    UniGene: Hs.32405