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  4. Phospho-PFKFB2 (S483) Antibody

Phospho-PFKFB2 (S483) Antibody

  • 货号：
    CSB-PA000708
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Hela cells using Phospho-PFK-2 car (S483) Polyclonal Antibody
    • Western Blot analysis of PC3 cells using Phospho-PFK-2 car (S483) Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O60825
  • 基因名：
  • 别名：
    6 phosphofructo 2 kinase/fructose 2 6 biphosphatase 2 antibody; 6-bisphosphatase antibody; 6-P2ase 2 antibody; 6-P2ASE heart-type isozyme antibody; 6PF 2 K/Fru 2 6 P2ASE heart type isozyme antibody; 6PF-2-K/Fru-2 antibody; 6PF-2-K/Fru-26-P2ase 2 antibody; 6PF-2-K/Fru-26-P2ase heart-type isozyme antibody; F262_HUMAN antibody; Fructose 2 6 bisphosphatase cardiac isozyme antibody; Fructose-2 antibody; PFK 2/FBPase 2 antibody; PFK/FBPase 2 antibody; PFKFB cardiac antibody; PFKFB2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human PFK-2 car around the phosphorylation site of S483.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Synthesis and degradation of fructose 2,6-bisphosphate.
  • 基因功能参考文献：
    1. UCA1/miR-182/PFKFB2 axis modulates chemokine CXCL14 secretion, glycolysis and invasion of glioma cells in glioblastoma-associated stromal cells . PMID: 29655792
    2. Crystal structure of human and cattle heart PFKFB2 and the inhibitory influence of citrate on substrate binding has been described. PMID: 27802586
    3. Variation in PFKFB2 appears to reduce PFKFB2 expression in adipose and kidney tissues, and thereby increase risk for adiposity and diabetic nephropathy. PMID: 25662186
    4. Highly expressed PFKFB2 protein is associated with hepatocellular carcinoma. PMID: 24568531
    5. bifunctionality of PFK-2/FBPase-2 complements the metabolic zonation of the liver by ensuring coherent switching in response to insulin and glucagon. PMID: 24634222
    6. amino acids stimulate Fru-2,6-P2 synthesis by Akt-dependent PFKFB2 phosphorylation and activation and show how signaling and metabolism are inextricably linked. PMID: 23457334
    7. A persistent increase in 6-phosphofructo-2-kinase produced by a change in PFK-2/FBPase-2 isoform expression that may play an important role in the regulation of muscle glycolysis. PMID: 22241065
    8. Suggest that PFKFB2 is not an essential upstream regulator of the anti-leukemic effects of glucocorticoids. PMID: 21092265
    9. induction of de novo lipid synthesis by androgen requires transcriptional up-regulation of HK2 and PFKFB2, and phosphorylation of PFKFB2 generated by the PI3K/Akt signal pathway to supply the source for lipogenesis from glucose in prostate cancer cells. PMID: 20958264
    10. Human islets expressed the PFKFB2 and PFKFB3 isoforms. PFK-2/FBPase-2 protein rather than its product fructose 2,6-P(2) is the over-riding determinant of glucose-induced insulin secretion through regulation of glucokinase activity PMID: 18039179

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  • 蛋白家族：
    Phosphoglycerate mutase family
  • 组织特异性：
    Heart.
  • 数据库链接：

    HGNC: 8873

    OMIM: 171835

    KEGG: hsa:5208

    STRING: 9606.ENSP00000356047

    UniGene: Hs.282702