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Phospho-NTRK2 (Tyr515) Antibody

  • 货号：
    CSB-PA197704
  • 规格：
    ￥2454
  • 图片：
    • Immunofluorescence staining of methanol-fixed Hela cells using TrkB(Phospho-Tyr515) Antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NTRK2 Polyclonal antibody
  • Uniprot No.：
    Q16620
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of tyrosine 515 (P-Q-Y(p)-F-G) derived from Human TrkB.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:100-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
  • 基因功能参考文献：
    1. MNX1 may directly regulate TrkB expression, which may increase their metastatic potential via suppression of anoikis and enhanced adhesion to the ECM. PMID: 30066929
    2. TRKB role in epithelial-mesenchymal transition, migration and invasion of cervical cancer. PMID: 29345295
    3. BDNF/TrkB axis plays a role in epithelial mesenchymal transition promoting the acquisition of (myo)fibroblast cell phenotype in idiopathic pulmonary fibrosis. PMID: 28938915
    4. Low TRKB expression is associated with Parkinson's disease. PMID: 28923922
    5. Study observed that patients with epilepsy might have a different variant distribution in the NTRK2 gene compared to controls without epilepsy, and that NTRK2 variability might influence age at seizure onset and possibly seizure control. PMID: 28863320
    6. Study reports that cells residing in the human subependymal zone (SEZ) may maintain their responsiveness to mature BDNF, although this responsiveness seems to undergo age-related alterations. Results indicate that TrkB-TK+ expression may promote neuronal differentiation, whereas TrkB-TK- expression may block neuronal differentiation in favour of neural precursor proliferation and/or glial differentiation. PMID: 28612959
    7. these findings demonstrate that TrkB-mediated signaling contributes to the induction of malignant phenotypes (proliferation, invasiveness, angiogenesis, lymphangiogenesis, and tumorigenesis) in gallbladder cancer PMID: 28423707
    8. our findings suggest that heterodimerization of Her2 and TrkB receptors gives breast cancer cells a survival advantage in the brain and that dual inhibition of these receptors may hold therapeutic potential PMID: 28446206
    9. TrkB-containing exosomes play a key role in the control of glioblastoma progression and aggressiveness, as seen in a model of YKL-40-inactivated glioblastoma cells PMID: 27385098
    10. Female sex and specific allelic variations in the NTRK2 gene were independently associated with mood disorders or depressive disorders in temporal lobe epilepsy patients. PMID: 28550723
    11. Report an association between antidepressant worsening suicidal ideation and SNP rs1439050 of NTRK2 in depressed subjects treated by tianeptine. PMID: 27378793
    12. This work demonstrates that DHF, through activation of TrkB signaling pathway, has a preventive function in d-glucose-induced apoptosis in PRE cells in diabetic retinopathy. PMID: 29109000
    13. The aim of the current review was to provide an overview of the role of BDNF/TrkB pathways in the pathogenesis of breast cancer and its value as a potential therapeutic target. PMID: 28230291
    14. Data suggest that high expression of TRKB (not TRKA or TRKC) in lung squamous cell carcinoma is correlated with vascular invasion, lymph node metastasis, advanced stage of tumor, and poor prognosis; overall survival of patients with TRKB-high expression is significantly shorter than those with TRKB-low expression; RNA interference against TRKB or BDNF (TRKB agonist) inhibits cell proliferation of tumor cell line. PMID: 28604655
    15. Among the adaptations observed following consumption of drugs of abuse or alcohol abuse, BDNF levels are widely altered in both brain and periphery. Data suggest that BDNF/TRKB signaling in neurons in specific areas of brain (hippocampus, nucleus accumbens) is altered in protracted withdrawal from drug/alcohol abuse. [REVIEW] PMID: 28215305
    16. High TRKB expression is associated with Small Cell Lung Cancer. PMID: 28870922
    17. High NTRK2 expression is associated with astrocytomas. PMID: 27402815
    18. overexpression of TrkB, but not of BDNF, is significantly associated with a poor survival outcome for TNBC patients. PMID: 28604807
    19. In the current work, we provide a global analysis of the physiological consequences of TrkB receptor activation in vitro and discuss the dynamic consequences of TrkB activation in vivo. Finally, we propose a clinically-feasible option for increasing BDNF expression in the hypothalamus to more readily utilize the oncolytic effects of BDNF. PMID: 28739680
    20. These findings, while exploratory, indicate that the genotypes of NTRK2 and COMT may contribute to relative risk for symptom burden during and shortly after the period of chemotherapy in women with early stage breast cancer. PMID: 28205449
    21. We demonstrated that downregulation of PHLDA1 leads to a significant increase in expression of Aurora A and TRKB that are markers of poor prognosis in neuroblastoma PMID: 27278006
    22. The receptors, TrkB and p75 are more highly expressed in deep infiltrating endometriosis than in peritoneal tissues. PMID: 27519317
    23. High expression of NTRK2 is associated with gastric cancer. PMID: 27662840
    24. Genetic variability of NTRK2, a susceptibility gene for psychiatric disorders, is related to emotional arousal and-independently-to brain white-matter properties in healthy individuals. PMID: 26978740
    25. High expression of TrkA, TrkB, or TrkC was significantly associated with histopathology PMID: 26459250
    26. Results show up-regulation of TrkB and down-regulation of Runx3 and Keap1 in breast cancer cells and suggest that TrkB plays a key role in tumorigenicity and metastasis of breast cancer cells through suppression of Runx3 or Keap1. PMID: 26657794
    27. Our data revealed that anoikis-resistant ACHN cells presented with tolerance to detachment-induced apoptosis, excessive proliferation and aggressive invasion, accompanied by upregulation of TrkB expression in contrast to parental cells PMID: 26820170
    28. results demonstrate the occurrence of ASIC2 and TrkB in the human intervertebral disc (IVD), and the increased expression of both in pathological IVD suggest their involvement in IVD degeneration PMID: 26617738
    29. Data indicate the role of tropomyosin-related kinase-B (TrkB) in activation of the interleukin-6/Janus kinase 2/STAT3 transcription factor and PI3 kinase/c-AKT proto-oncogene protein pathway in breast cancer. PMID: 26515594
    30. soluble Abeta42 and BDNF, but not TrkB or soluble tau, correlate with dementia in the oldest-old PMID: 26410307
    31. The rare variants in NTRK2 were significantly associated with smoking status. PMID: 25450229
    32. Entrectinib inhibits growth of TrkB expressing neuroblastoma cells in vitro and in vivo, and that it enhances the efficacy of conventional chemotherapy in in vivo models. PMID: 26797418
    33. Single-nucleotide polymorphisms rs1778929 and rs1187323 in the TrkB gene are significantly associated with post-stroke depression in the Chinese population. PMID: 26641254
    34. TrkB protein was mainly expressed in eutopic endometrium of proliferative phase with EMs than that in eutopic endometrium of secretory phase PMID: 27048022
    35. Results highlight the importance of brain-derived neurotrophic factor-induced tropomyosin receptor kinase B receptor signaling in rescuing Huntington's disease-mediated apoptotic features in striatal cells. PMID: 25896770
    36. Demonstrate that TrkB protects endothelial integrity during atherogenesis by promoting Ets1-mediated VE-cadherin expression and plays a previously unknown protective role in the development of coronary artery disease. PMID: 25633318
    37. Excessive activation of TrkB was found to promote epilepsy in a transgenic mouse model. PMID: 26481038
    38. This study demonstrated that TrkB expression in brain in patient with schizophrenia, bipolar disorder, and major depressive disorder. PMID: 25796564
    39. Our study showed that AZD6918 induced cell death as a single agent and attenuated BDNF/TrkB-induced protection from etoposide in vitro. PMID: 25700942
    40. Our results suggest that genetic variability in FKBP5 and NTRK2 genes may partially explain clinical response to clozapine PMID: 25751398
    41. Membranous/cytoplasmic TrkB may promote an epithelial-mesenchymal transition (EMT)-like phenotype with high-grade budding and maintain viability of buds themselves. PMID: 25382057
    42. The role of NTRK2 in in paranoid schizophrenia development in Russians. PMID: 26410934
    43. TrkB expression in lung adenoma cells is an early step in tumor cell dissemination. PMID: 24959744
    44. mRNA expression of NTRK2 genes was higher in low-grade gliomas vs. high-grade and control samples. Poor survival was associated with NTRK2 mRNA. Promoter methylation does not regulate NTRK2 genes in glioma. PMID: 24840578
    45. these results reinforce the role of NTRK2 gene in the pathogenesis of suicide. PMID: 25110312
    46. study demonstrated that the BDNF/TrkB axis promotes the migration and invasion of SACC cells via EMT in vitro PMID: 25456007
    47. Results present evidence of a role for BBS4 in mediating the phosphorylation of TrkB by BDNF and its activation requires a proper localization to the ciliary axoneme. PMID: 24867303
    48. Site-specific differential methylation in the TrkB-T1 3'UTR region associates with functional changes in TrkB-T1 expression and may play a significant role in the important decrease of cortical TrkB-T1 expression observed among suicide completers. PMID: 24802768
    49. TrkB-EGFR-sortilin (TES) complex in exosomes has a function in the activation and migration of endothelial cells. PMID: 25037567
    50. BDNF and TrkB are involved in vessel formation and osteogenic processes during human fracture healing PMID: 24984919

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  • 相关疾病：
    Obesity, hyperphagia, and developmental delay (OBHD)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 组织特异性：
    Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cor
  • 数据库链接：

    HGNC: 8032

    OMIM: 600456

    KEGG: hsa:4915

    STRING: 9606.ENSP00000277120

    UniGene: Hs.494312