Phospho-NFKBIB (T19) Antibody
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货号:CSB-PA020117
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规格:¥880
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图片:
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其他:
产品详情
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Uniprot No.:Q15653
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基因名:
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别名:I kappa B beta antibody; I-kappa-B-beta antibody; IkappaBbeta antibody; IKB beta antibody; IkB-B antibody; IkB-beta antibody; IKBB antibody; IKBB_HUMAN antibody; IkBbeta antibody; NF kappa BIB antibody; NF-kappa-B inhibitor beta antibody; NF-kappa-BIB antibody; Nfkbib antibody; Thyroid receptor interacting protein 9 antibody; Thyroid receptor-interacting protein 9 antibody; TR interacting protein 9 antibody; TR-interacting protein 9 antibody; TRIP-9 antibody; TRIP9 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Synthesized peptide derived from Human IκB-β around the phosphorylation site of T19.
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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产品提供形式:Liquid
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应用范围:WB, IHC, ELISA
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
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基因功能参考文献:
- The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib. PMID: 28314790
- data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB. PMID: 28448456
- our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway. PMID: 26227166
- NFKBIBrs3136641TT single nucleotide polymorphism was associated with a significantly decreased risk of developing wheezing. PMID: 25326706
- IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis PMID: 12475944
- VEGF increased Mn-superoxide dismutase promoter activity, an effect that was dependent on a second intronic NF-kappaB consensus motif. PMID: 15308628
- data indicate that inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta PMID: 15919917
- None of the NFKBIB SNPs are associated with pneumococcal susceptibility. PMID: 17463416
- increased I-kappaBbeta expression reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGase 2 polymerization. PMID: 18950638
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亚细胞定位:Cytoplasm. Nucleus.
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蛋白家族:NF-kappa-B inhibitor family
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组织特异性:Expressed in all tissues examined.
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数据库链接:
HGNC: 7798
OMIM: 604495
KEGG: hsa:4793
STRING: 9606.ENSP00000312988
UniGene: Hs.9731
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