Phospho-KCNIP3 (S63) Antibody

1. TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets. PMID: 30451831
2. targeting SmgGDS induces nucleolar stress, resulting in profound loss of DREAM target gene expression required for G1, S and G2 progression, and ultimately resulting in cell cycle arrest. PMID: 28806394
3. Disruption of DREAM and RB-E2F complexes by oncoproteins from DNA tumor viruses leads to upregulation of cell cycle genes and impairs growth-inhibiting pathways, including the p53-mediated downregulation of cell cycle genes. [review] PMID: 28799433
4. This study shows the application of hydrogen-deuterium exchange mass spectrometry and site-directed mutagenesis to investigate the Ca(2+) binding properties and the subsequent conformational changes of full-length DREAM. EF-hands undergo large conformation changes upon calcium binding even though the EF-1 hand is not capable of binding to Ca(2+). PMID: 28627884
5. Our approach yields high confidence ranked target gene maps for TP53, DREAM, MMB-FOXM1 and RB-E2F and enables prediction and distinction of CC regulation. A web-based atlas at www.targetgenereg.org enables assessing the regulation of any human gene of interest. PMID: 27280975
6. downregulation of these genes through the p53-p21-DREAM-CDE/CHR pathway appears to be a principal mechanism for G2/M cell cycle arrest by p53. PMID: 26384566
7. The aim of this study was to investigate somatic mutations and DREAM gene expression in human multinodular goiter PMID: 26319784
8. Imatinib induces GIST cell quiescence in vivo and that this process also involves the DREAM complex. PMID: 23786773
9. Our results support the hypothesis that KChIPs enhances Kv4.2 functional expression by a 1 : 1 suppression of the N-terminal FERN domain and by producing additional positive regulatory effects on functional channel expression. PMID: 23692269
10. GCM1-directed villous trophoblast differentiation is repressed by DREAM PMID: 23300953
11. p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements. PMID: 23187802
12. Genetic variation in the DREAM pathway genes was associated with the extent of pain reporting in a population-based cohort. PMID: 22730276
13. The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function. PMID: 23019329
14. expression of calsenilin leads to a disruption of presenilin 1/gamma-secretase-mediated epsilon-cleavage of N-cadherin, which results in the significant accumulation of N-cadherin C-terminal fragment 1 PMID: 21852538
15. The results show that continued human papillomavirus 16 E6/E7 expression is necessary in cervical cancer cells to prevent cell-cycle arrest by a repressive p130-DREAM complex. PMID: 21813705
16. These findings suggest that calsenilin degradation is primarily mediated by the UPP and that impairment in the UPP may contribute to the involvement of calsenilin in disease-associated neurodegeneration. PMID: 21216226
17. apoptosis inducers as diverse as oncoprotein inhibitors and cell death receptor activators trigger Hrk expression via blockade of DREAM in leukemia cells PMID: 12217801
18. Immunoreactivity of calsenilin in the hippocampus derived from an epilepsy patient is significantly decreased compared with normal brain. PMID: 12648752
19. calsenilin can be phosphorylated by casein kinase I and that its phosphorylation can be regulated by intracellular calcium. PMID: 12837631
20. The level of intracellular calcium can modulate the nuclear translocation of calsenilin and this process does not involve the direct binding of calcium to calsenilin PMID: 15086516
21. Calsenilin overexpression in both neurons and reactive astrocytes may play an important role in apoptosis and in Alzheimer's disease pathology. PMID: 15770150
22. DREAM is a Ca2+-dependent repressor of the immune response. PMID: 16177826
23. The downregulation of the regulator of Ca2+ homeostasis NCX3 by Ca2+-regulated DREAM is a striking example of the autoregulatory property of the Ca2+ signal in neurons. PMID: 16306395
24. DREAM plays an important role in human calcitonin gene expression in a Ca(2+)- and cAMP-dependent manner PMID: 16840549
25. interaction of DREAM with GRK6 and GRK2, members of the G protein-coupled receptor kinase family of proteins, and their phosphorylation of DREAM PMID: 17102134
26. analysis of calcium-binding properties of EF-hands 3 and 4 of calsenilin PMID: 17962406
27. CALP and calsenilin are involved in the trafficking of Golgi glycosyltransferases. PMID: 18269347
28. These results reveal a new role for KChIP3 in the regulation of calcium regulated secretion and also suggest that the functions of each of the KChIPs may be more specialized than previously appreciated. PMID: 18393943
29. DREAM transcripts are present in synovial fibroblast-like cells as well as peripheral blood mononuclear cells from osteoarthritis patients and healthy controls. PMID: 18507845
30. Data show that calsenilin/DREAM/KChIP3 is distributed throughout the cytoplasm of SK-N-BE2(C), Jurkat, and HeLa cells and the expression of calsenilin suppresses the ATP-induced increase in intracellular Ca2+ concentrations. PMID: 18628663
31. Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling PMID: 18664571
32. KChIP4a, KChIP2x, and KChIP3x comprise a novel class of KChIP isoforms characterized by an unusual transmembrane domain at their N termini that modulates Kv4 channel gating and trafficking. PMID: 18957440
33. DREAM (downstream regulatory element antagonist modulator) modulates TSHR activity through a direct protein-protein interaction that promotes coupling between the receptor and Galphas. PMID: 19299442

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HGNC: 15523

OMIM: 604662

KEGG: hsa:30818

STRING: 9606.ENSP00000295225

UniGene: Hs.437376