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  4. Phospho-JUND (Ser255) Antibody

Phospho-JUND (Ser255) Antibody

  • 货号：
    CSB-PA843368
  • 规格：
    ￥2454
  • 图片：
    • Western blot analysis of extracts from 293 cells using JunD(Phospho-Ser255) Antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).
    • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using JunD(Phospho-Ser255) Antibody(left) or the same antibody preincubated with blocking peptide(right).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) JUND Polyclonal antibody
  • Uniprot No.：
    P17535
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of serine 255 (G-E-S(p)-P-P) derived from Human JunD.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor binding AP-1 sites.
  • 基因功能参考文献：
    1. Data indicate the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and suggest structural insight for therapeutic interventions targeting AP-1 proteins. PMID: 28981703
    2. In T cells, after serum deprivation HBZ induces the expression of Delta JunD isoform. Unlike JunD, Delta JunD induces proliferation and transformation of cells. HBZ bypasses translational control of JunD uORF and favors the expression of Delta JunD. The truncated isoform Delta JunD has a central role in the oncogenic process leading to adult T-cell leukemia . PMID: 28260789
    3. MiR-663a suppresses proliferation and invasion by targeting AP-1 component JunD in non-small cell lung cancer cells. PMID: 27184257
    4. studies showed that down-regulation of JunD in response to TGF-beta treatment is mediated via the proteasomal degradation pathway. PMID: 27358408
    5. recombinant SERPINE2 induced a clear inhibition of MMP-13 expression in IL-1alpha-stimulated chondrocytes. This inhibitory effect is likely regulated through a pathway involving ERK 1/2, NF-kappaB and AP-1 PMID: 26305372
    6. miR-494 is a novel regulator of HNPC apoptosis induced by TNF-alpha PMID: 25906693
    7. JunD activates miR-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD PMID: 25788572
    8. Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3- JUND expression. PMID: 24658685
    9. BAG3 stabilized JunD mRNA. PMID: 24140207
    10. This genotype-phenotype correlation study confirmed the lack of direct genotype-phenotype correlations. However, patients with mutations affecting the JunD interacting domain had a higher risk of death secondary to a MEN1 tumor PMID: 23376981
    11. HTLV-1 bZIP factor(hbz) requires cellular JunD to upregulate HTLV-1 antisense transcription from the 3' long terminal repeat. PMID: 22696638
    12. results demonstrate the presence of a common oncogenic cascade initiated by FRA2/JUND in CCR4-expressing mature T-cell malignancies such as ATLL and CTCLs PMID: 22493372
    13. crystal structures of human menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1-LEDGF heterodimer PMID: 22327296
    14. Apoptosis induction by dominant negative JunD is due to induction of growth arrest and DNA damage inducible proteins (GADD) 45 alpha and 45 gamma proteins. PMID: 21734453
    15. JunD mediates, whereas c-Jun modulates, prostaglandin E2 activation of aromatase promoters PMID: 21393445
    16. data indicate that JunD is an inhibitor of RHOH gene expression. PMID: 21473742
    17. These results suggest that the induction of MMP-7 by Tax is regulated by JunD and that MMP-7 could facilitate visceral invasion in adult T-cell leukemia . PMID: 21315773
    18. An alternative model of H ferritin promoter transactivation by c-Jun PMID: 11903046
    19. JunD activated by LHRH acts as a modulator of cell proliferation and cooperates with the anti-apoptotic and anti-mitogenic functions of LHRH. PMID: 12054733
    20. junD activation by ultraviolet rays plays a role in apoptosis in myeloblastic leukemia ML-1 cells PMID: 12082101
    21. Translation initiation from alternative AUG and non-AUG sites in human, mouse and rat. PMID: 12105216
    22. Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. PMID: 12727841
    23. Menin is important for recruiting an mSin3A-histone deacetylase complex to repress JunD transcriptional activity. PMID: 14559791
    24. Data show that human T-cell leukemia virus type I (HTLV-I) bZIP factor can activate JunD-dependent transcription and that its amino-terminus is required. PMID: 15044019
    25. menin suppresses osteoblast maturation, in part, by inhibiting the differentiation actions of JunD PMID: 15563473
    26. JunD is another ARE regulatory protein for transcriptional activation of the human ferritin H gene and probably other antioxidant genes containing the conserved ARE sequences by which JunD may confer cytoprotection during oxidative stress PMID: 16007120
    27. JunD limits cardiomyocyte hypertrophy and protects the pressure-overloaded heart from cardiac apoptosis PMID: 16129800
    28. Menin's dynamic regulation of histone modifiers with JunD is responsible for PKC theta-synergistic effect on Nur77 expression in T cell PMID: 16264271
    29. Our data suggest that JUND and CLDN4 are critical mediators of the antiproliferative and antiviral effects of type I IFNs and further confirm the functional importance of the DNA-binding domain of Stat2. PMID: 17651017
    30. aberrantly expressed Fra-2 in association with JunD may play a major role in CCR4 expression and oncogenesis in adult t-cell leukemia. PMID: 18071306
    31. evidence is provided that HBZ/JunD heterodimers interact with Sp1 transcription factors and that activation of hTERT transcription by these heterodimers is mediated through binding sites for Sp1 present in the hTERT promoter. PMID: 18078517
    32. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953
    33. JunD overexpression increases production of reactive oxygen species in LNCaP cells in a low androgen environment. PMID: 18386285
    34. JunD is a major determinant of macrophage activity and is associated with glomerulonephritis susceptibility. PMID: 18443593
    35. JunD activation reduces the proliferation of cancer cells. PMID: 18454173
    36. JunD is a biological suppressor of ZO-1 expression in intestinal epithelial cells and plays a critical role in maintaining epithelial barrier function PMID: 18562690
    37. Activated c-Jun is dimerized with JunD in response to adrenomedullin. PMID: 19166930
    38. Data suggest that TGF-beta1 up-regulates angiotensinogen transcription through a mechanism that requires both JunD and HIF-1alpha binding to the AGT core promoter, and that a molecular mechanism links hypoxia signaling and fibrogenic stimuli in the lung. PMID: 19211927
    39. Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. PMID: 19470832

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, Jun subfamily
  • 数据库链接：

    HGNC: 6206

    OMIM: 165162

    KEGG: hsa:3727

    STRING: 9606.ENSP00000252818

    UniGene: Hs.2780