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  4. Phospho-ICK (Y159) Antibody

Phospho-ICK (Y159) Antibody

  • 货号：
    CSB-PA008265
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 3T3 cells using Phospho-Intestinal Cell Kinase (Y159) Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UPZ9
  • 基因名：
    ICK
  • 别名：
    CILK1 antibody; ICK antibody; KIAA0936Serine/threonine-protein kinase ICK antibody; EC 2.7.11.1 antibody; Ciliogenesis associated kinase 1 antibody; Intestinal cell kinase antibody; hICK antibody; Laryngeal cancer kinase 2 antibody; LCK2 antibody; MAK-related kinase antibody; MRK antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human Intestinal Cell Kinase around the phosphorylation site of Y159.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity.
  • 基因功能参考文献：
    1. Our data provide evidence that heterozygous variants in ICK caused juvenile myoclonic epilepsy in 7% of the patients included in our analysis. Variant ICK affects cell processes that help explain microdysgenesis and polyspike networks observed on EEG in juvenile myoclonic epilepsy. PMID: 29539279
    2. These data identify ICK as an short rib polydactyly syndromes (SRPS)-associated gene and reveal that abnormalities in signalling pathways contribute to defective skeletogenesis PMID: 27466187
    3. findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress. PMID: 25184386
    4. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. PMID: 24244486
    5. In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation. PMID: 23743448
    6. High ICK expression is associated with prostate cancer. PMID: 22761715
    7. an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor Thr-908. PMID: 22356909
    8. ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity PMID: 19185282
    9. Findings demonstrate an important role for ICK in proliferation and differentiation of intestinal epithelial cells. PMID: 19696144
    10. ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. PMID: 20459822
    11. PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe, an essential regulator of proliferation and apoptosis during mammalian development. PMID: 16954377
    12. ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1, c-Myc and p21Cip1. PMID: 19696144
    13. ICK is the prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs. PMID: 15988018

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  • 相关疾病：
    Endocrine-cerebroosteodysplasia (ECO)
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 组织特异性：
    Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
  • 数据库链接：

    HGNC: 21219

    OMIM: 612325

    KEGG: hsa:22858

    STRING: 9606.ENSP00000263043

    UniGene: Hs.417022