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Phospho-HDAC4 (Ser632) Antibody

  • 货号：
    CSB-PA247261
  • 规格：
    ￥2454
  • 图片：
    • Western blot analysis of extracts from 293 cells untreated(lane 1) or treated with EGF(lane 2) using HDAC4(Phospho-Ser632) Antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HDAC4 Polyclonal antibody
  • Uniprot No.：
    P56524
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of serine 632 (A-Q-S(p)-S-P) derived from Human HDAC4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
  • 基因功能参考文献：
    1. we suggest that STAT1HDAC4 signaling induces malignant tumor features such as EMT and sphere formation in CUG2overexpressing cancer cells. PMID: 30226605
    2. MiR-22 was up-regulated in CD4+ T cells in peripheral blood and intestinal mucosa tissues of inflammatory intestinal disease patients, which could promote Th17 cell differentiation via targeting HDAC4 to be involved in inflammatory intestinal disease progression PMID: 29880327
    3. HO-1 plays a key role in protecting tumor cells from apoptosis, in a process that involves Smad7 and HDAC4/5 in apoptosis of B-ALL cells PMID: 29886060
    4. Auithors found no significant association between the previously implicated CpG in HDAC4 and either AN or BN. We found that three CpGs were nominally associated with AN (P=0.02-0.03); the largest difference was a 9% hypermethylation in AN. PMID: 29256967
    5. our results demonstrated that MIAT competitively binds to miR-29a-3p and consequently upregulates the expression of HDAC4, which is a downstream target of miR-29a-3p. In conclusion, the present study highlighted the involvement of the MIAT/miR-29a-3p/HDAC4 axis in the development of Gastric cancer (GC), which provided potential diagnostic and therapeutic targets for GC. PMID: 29039602
    6. miR-29a regulated osteogenesis of the subchondral mesenchymal stem cells through modulation of HDAC4 and Wnt3a. PMID: 28884332
    7. Results show that HDAC4 promoter methylation is inversely associated with arachidonic acid post-prandially in adult males. PMID: 27181711
    8. The cytoplasmic location and function of HDAC4 is controlled by the activity of salt-inducible kinase (SIK). These results establish a cytoplasmic role for HDAC4 and identify HDAC4, SIK, and ENIGMA as mediators of vascular calcification. PMID: 28588072
    9. Strong correlation has been proved between the expression levels of HDAC4 and SIRT6. PMID: 27766571
    10. HDAC4 regulates thimerosal-induced cell death in neurons and that treatment with MC1568 prevents thimerosal-induced activation of caspase-3 in the rat prefrontal cortex. PMID: 27660204
    11. HDAC4 promotes proliferation and G1/S cell cycle progression in esophageal carcinoma cells by inhibiting CDK inhibitors p21 and p27 and up-regulating CDK2/4 and CDK-dependent Rb phosphorylation. HDAC4 also enhances ESCC cell migration. Furthermore, HDAC4 positively regulates epithelial-mesenchymal transition (EMT) by increasing the expression of Vimentin and decreasing the expression of E-Cadherin/alpha-Catenin. PMID: 27295551
    12. level of myotubes MTM1 mutations do not dramatically affect calcium homeostasis and calcium release mediated through the ryanodine receptor 1, though they do affect myotube size and nuclear content..mature muscles such as those obtained from patient muscle biopsies exhibit a significant decrease in expression of the ryanodine receptor 1, a decrease in muscle-specific microRNAs and a considerable up-regulation of HDAC4. PMID: 28007904
    13. 7-amino-4-methylcoumarin did not affect acetyllysine preference in a multiply acetylated substrate. In contrast, AMC significantly enhanced KDAC6 substrate affinity, greatly reduced Sirt1 activity, eliminated the substrate sequence specificity of KDAC4, and had no consistent effect with KDAC8 substrates. PMID: 28749131
    14. Suggest that HDAC4 and HDAC6 are guardians of irradiation-induced DNA damage and stemness, thus promoting radioresistance in glioblastoma cells. PMID: 28342984
    15. TGF-beta1 increases NADPH oxidase 4 (NOX4) mRNA and protein expression in normal human lung fibroblasts (NHLFs) and causes nuclear export of HDAC4. PMID: 28336812
    16. elevated HO-1 produced less reactive oxygen species, resulting in nuclear localization of HDAC4 and miR-206 repression. PMID: 27488535
    17. Results show that HDAC4 is a direct target of miR-29b in multiple myeloma cells and its high mRNA expression inversely correlates with miR-29b levels in multiple myeloma samples. PMID: 27196750
    18. Collectively, we suggest that VSV treatment will be a useful therapeutic strategy for HCV-infected hepatocellular carcinoma cells because HCV core protein suppresses the anti-viral threshold by down-regulation of the STAT1-HDAC4 signaling axis. PMID: 27150631
    19. In osteoarthritis (OA) chondrocytes, hydrostatic pressure (HP) restores the expression levels of some miRNAs, downregulates MMP-13, ADAMTS-5, and HDAC-4, and modulates the Wnt/beta-catenin pathway activation. PMID: 28085114
    20. HDAC4 is a target gene of miR-140 and is involved in miR-140-mediated suppression of osteosarcoma cells. PMID: 27624383
    21. HDAC4 increases endogenous SIRT1 expression by enhancing its sumoylation modification levels PMID: 26414199
    22. downregulated in sustained virologic responders compared to the spontaneous clearers of Hepatitis C PMID: 26568966
    23. we demonstrate that nuclear HDAC4 is a key regulator promoting the progressive epithelial ovarian cancer on fibrillar collagen matrices PMID: 26572940
    24. HDAC4 destabilizes MAP1S, suppresses autophagy flux and promotes the accumulation of mHTT aggregates. PMID: 26540094
    25. Mechanical compression regulates chondrocyte gene expression through HDAC4 relocation from the cell's cytoplasm to the nucleus via PP2A-dependent HDAC4 dephosphorylation. PMID: 27106144
    26. Elevated HDAC-4 expression in Pancreatic Adenocarcinoma was significantly associated with the absence of organ metastases and borderline with the absence of lymph node metastases and tumor proliferative capacity. PMID: 26502922
    27. Over-expression of HDAC4 suppressed the transcription of genes involved in energy expenditure in a SIRT1-dependent manner. In contrast, HDAC4 knockdown/inhibition neutralized the effect of IFN-gamma on cellular metabolism by normalizing SIRT1 expression PMID: 26619800
    28. HDAC4-RelB-p52 complex maintains repressive chromatin around proapoptotic genes Bim and BMF and regulates multiple myeloma survival and growth PMID: 26455434
    29. Results show that overexpression of miR10b in ER-positive breast cancer cell lines led to increased resistance to tamoxifen and HDAC4 was identified as its direct target. MiR10b-HDAC4 nexus may be one of the molecular mechanism of tamoxifen resistance. PMID: 26206152
    30. the pro-inflammatory role of miR-22 in emphysema has revealed that HDAC4 specifically regulated smoking-related lung inflammation and TH17 responses PMID: 26437241
    31. This study leads to the discovery of a novel molecular mechanism in which the miRNA miR-125a-5p suppresses HDAC4 expression PMID: 25504437
    32. Dysregulation of HDAC4 and/or HDAC6 could play a role in the pathogenesis of Frontotemporal lobar degeneration-tau associated with Pick bodies PMID: 24861260
    33. Idiopathic pulmonary fibrosis fibroblast interaction with polymerized type I collagen results in an aberrant PP2A/HDAC4 axis, which suppresses miR-29, causing a pathologic increase in type I collagen expression. PMID: 25612003
    34. Decreased HDAC4 partially contributes to the pathogenesis of osteoarthritis cartilage degeneration. PMID: 25424126
    35. Data suggeet the potential clinical use of histone deacetylase 4 (HDAC4) inhibitors in combination with docetaxel for the treatment of gastric cancer. PMID: 25091122
    36. observations suggested that some other candidate genes for neuronal development exist in the telomeric region of HDAC4 PMID: 25329715
    37. Increased expression of HDAC4 was found in cartilage from knee osteoarthritis patients. PMID: 25515592
    38. Haploinsufficiency of HDAC4 does not cause intellectual disability in all affected individuals. PMID: 24715439
    39. We demonstrated that HDAC4 promotes gastric cancer cell progression mediated through the repression of p21. PMID: 24896240
    40. expression of the proliferation marker Ki-67 exhibited a similar tendency with that of HDAC4 PMID: 25103231
    41. Thus, HDAC4 contributes to podocyte injury and is one of critical components of a signal transduction pathway that links renal injury to autophagy in diabetic nephropathy. PMID: 24717296
    42. novel HDAC1/4/miR-200b/E2F3 signaling contributes to chemoresistance of human lung adenocarcinoma cells PMID: 24830600
    43. Data show that HDAC4 plays global roles in the regulation of gene transcription, cell growth, survival and proliferation, and their aberrant expression or activity leads to cancer development. PMID: 24579951
    44. Results show that HDAC4 is the Upstream 6PGD Deacetylase that removes acetylation from both K76 and K294 sites. PMID: 25042803
    45. HDAC4 played an important role in the regulation of Endoplasmic reticulum stress-induced apoptosis through interacting with ATF4 and inhibiting its transcriptional activity. PMID: 24308964
    46. The expression pattern of HDAC4 in obese subjects before and after physical exercise, its correlation with various physical, clinical and metabolic parameters and its inhibitory effect on NF-kappaB are suggestive of a protective role against obesity. PMID: 24086512
    47. EZH2 and HDAC4 represent mutually exclusive epigenetic pathways across human cancers PMID: 24079712
    48. Increased HDAC4 expression is associated with chemoresistance in breast cancer. PMID: 23817620
    49. analysis of eight members across four generations identified a missense mutation in the histone deacetylase 4 (HDAC4) gene that segregated with eating disorders PMID: 24216484
    50. Correlation studies depicted two distinct groups of soft tissue sarcomas: one in which MEF2 repression correlates with PTEN downregulation and a second group in which MEF2 repression correlates with HDAC4 levels. PMID: 24043307

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  • 相关疾病：
    Brachydactyly-mental retardation syndrome (BDMR)
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Histone deacetylase family, HD type 2 subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 14063

    OMIM: 600430

    KEGG: hsa:9759

    STRING: 9606.ENSP00000264606

    UniGene: Hs.20516