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  4. Phospho-HCLS1 (Tyr397) Antibody

Phospho-HCLS1 (Tyr397) Antibody

  • 货号：
    CSB-PA258754
  • 规格：
    ￥2454
  • 图片：
    • Western blot analysis of extracts from JK cells (Lane 2), using HS1 (Phospho-Tyr397) Antibody.The lane on the left is treated with antigen-specific peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HCLS1 Polyclonal antibody
  • Uniprot No.：
    P14317
  • 基因名：
    HCLS1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence around phosphorylation site of tyrosine 397(G-D-Y(p)-E-E) derived from Human HS1 .
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
  • 基因功能参考文献：
    1. these studies indicate HS1 plays an important role in ROR1-dependent Wnt5a-enhanced chemokine-directed leukemia-cell migration. PMID: 28465529
    2. SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells. PMID: 25359136
    3. Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. PMID: 23017497
    4. interaction of HCLS1 with LEF-1 is essential for G-CSF-triggered myeloid differentiation; data demonstrate the importance of HCLS1 in myelopoiesis in vitro and in vivo PMID: 23001182
    5. HS1 overexpressed in leukemic as compared to normal B lymphocytes. PMID: 22768161
    6. a novel role for HS1 and its phosphorylation during neutrophil directed migration. PMID: 22679023
    7. High HS1 expression predicts poor survival of chronic lymphocytic leukemia patients. PMID: 22333038
    8. SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs. PMID: 21287358
    9. HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in chronic lymphocytic leukemia. PMID: 20530793
    10. substrate for caspase cleavage during apoptosis PMID: 11689006
    11. TBB induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. PMID: 11988074
    12. found in cell types other than hematopoietic cells PMID: 15754022
    13. HS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets PMID: 15795233
    14. The HS1 coiled-coil region acts synergistically with the repeat domain in the modulation of the Arp2/3 complex-mediated actin polymerization. PMID: 16157603
    15. HS1 may play a role in cytoskeleon organization in B-cells and leukemic B-cells PMID: 17508001

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  • 亚细胞定位：
    Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion.
  • 组织特异性：
    Expressed only in tissues and cells of hematopoietic origin.
  • 数据库链接：

    HGNC: 4844

    OMIM: 601306

    KEGG: hsa:3059

    STRING: 9606.ENSP00000320176

    UniGene: Hs.14601