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  4. Phospho-FER (Y402) Antibody

Phospho-FER (Y402) Antibody

  • 货号：
    CSB-PA008235
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P16591
  • 基因名：
    FER
  • 别名：
    c FER antibody; Feline encephalitis virus related kinase FER antibody; Fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) antibody; Fer (fps/fes related) tyrosine kinase antibody; FER antibody; FER_HUMAN antibody; FerT antibody; Fujinami poultry sarcoma/Feline sarcoma related protein Fer antibody; p94 FER antibody; p94-FER antibody; Pe1Fe10 antibody; Pe1Fe13 antibody; Pe1Fe3 antibody; Pe1Fe6 antibody; Phosphoprotein NCP94 antibody; PPP1R74 antibody; Protein phosphatase 1 regulatory subunit 74 antibody; Proto oncogene tyrosine protein kinase FER antibody; Proto-oncogene c-Fer antibody; TYK3 antibody; Tyrosine kinase 3 antibody; Tyrosine-protein kinase Fer antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human Fer around the phosphorylation site of Y402.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
  • 基因功能参考文献：
    1. Data show that FER tyrosine kinase (Fer/FerT) activity was disrupted by E260, which selectively evokes metabolic stress in cancer cells by imposing mitochondrial dysfunction and deformation. PMID: 29038547
    2. We propose a model for the regulation of Fer based on an intramolecular interaction and the curvature-dependent membrane binding mediated by its intrinsically disordered region. PMID: 29208465
    3. Many human tumor types and cancer cell lines express the MAN2A1-FER fusion, which increases proliferation and invasiveness of cancer cell lines and has liver oncogenic activity in mice. PMID: 28245430
    4. Fer serves as a crucial mediator and amplifier of Src-induced tumor progression. PMID: 25867068
    5. FER encodes a cytosolic non-receptor tyrosine kinase that influences neutrophil chemotaxis and endothelial permeability. PMID: 25533491
    6. Fer contributes to aberrant androgen receptor signaling via pSTAT3 cross-talk during castrate-resistant prostate cancer progression. PMID: 23906537
    7. Detection of PJA2-FER fusion mRNA is correlated with poor postoperative survival periods in non-small cell lung cancer. PMID: 23931849
    8. data show that Fer kinase is elevated in non-small cell lung cancer tumors and is important for cellular invasion and metastasis PMID: 23699534
    9. FER kinase promotes breast cancer metastasis by regulating alpha6- and beta1-integrin-dependent cell adhesion and anoikis resistance. PMID: 23873028
    10. Fer expression correlates with renal cell carcinoma cell proliferation both in vitro and in vivo, and with tumor progression and survival PMID: 23445469
    11. Fer, a non-receptor-type tyrosine kinase, plays a critical role in synthesis of the laminin-binding glycans on alpha-DG. PMID: 22238358
    12. Transcription of the ferT gene in CC cells was found to be driven by an intronic promoter residing in intron 10 of the fer gene and to be regulated by the Brother of the Regulator of Imprinted Sites (BORIS) transcription factor. PMID: 22223638
    13. The A allele of SNP rs10447248 in the FER locus was nominally associated with lower MMW (P = 0.016) but was not associated with LMW (P > 0.05) adiponectin levels PMID: 21700879
    14. Overexpression of FER from a cDNA confers quinacrine resistance to several different types of cancer cell lines. PMID: 21518868
    15. tyrosine phosphorylation of RhoGDIalpha by Fer as a mechanism to regulate binding of RhoGDIalpha to Rac PMID: 21122136
    16. FER plays a role in the invasion and metastasis of hepatocellular carcinoma cells. PMID: 19835603
    17. Closing in on the biological functions of Fps/Fes and Fer. A review. PMID: 11994747
    18. Fps/Fes and Fer are expressed in human and mouse platelets, and are activated following stimulation with collagen and collagen-related peptide (CRP), suggesting a role in GPVI receptor signaling PMID: 12871378
    19. Fer is a regulator of cell-cycle progression in malignant cells and a potential target for cancer intervention. PMID: 16732323
    20. FerT coexist in the acroplaxome with phosphorylated cortactin, a regulator of F-actin dynamics[Fer testis ] PMID: 18985748
    21. Fer tyrosine kinase level correlates with the development of prostate cancer and aggressiveness of prostate cancer cell lines PMID: 19147545
    22. Results suggest that Fer may allow a bypass of focal adhesion kinase-related cell anchorage dependency for intracellular signal transduction in hepatocytes. PMID: 19339212
    23. Overexpression of Fer enhanced lamellipodia formation and cell migration in a manner dependent on PLD activity and the PA-FX interaction. PMID: 19738202

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Fes/fps subfamily
  • 组织特异性：
    Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level).
  • 数据库链接：

    HGNC: 3655

    OMIM: 176942

    KEGG: hsa:2241

    STRING: 9606.ENSP00000281092

    UniGene: Hs.107418