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  4. Phospho-ACAP1 (S554) Antibody

Phospho-ACAP1 (S554) Antibody

  • 货号：
    CSB-PA080059
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q15027
  • 基因名：
  • 别名：
    ACAP 1 antibody; ACAP1 antibody; ACAP1_HUMAN antibody; Arf GAP with coiled coil ANK repeat and PH domains 1 antibody; Arf GAP with coiled coil; ankyrin repeat; and pleckstrin homology domains 1 antibody; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1 antibody; ArfGAP with coiled-coil; ankyrin repeat and PH domains 1 antibody; CENT B1 antibody; Centaurin beta 1 antibody; Centaurin-beta-1 antibody; CENTB 1 antibody; Cnt b1 antibody; Cnt-b1 antibody; Cntb1 antibody; KIAA0050 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from Human ACAP1 around the phosphorylation site of S554.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
  • 基因功能参考文献：
    1. The serum lever of Alzheimer's disease were decrease and the expression of ACAP1 strongly correlated with the Mini-Mental State Examination scores of the AD patients PMID: 25502766
    2. ACAP1 and ARAP2 each colocalize with Arf6 but they did not colocalize with each other and have opposing effects on focal adhesions. PMID: 25225293
    3. CENTB1 was up-regulated in patients with active UC as compared to UC remission and healthy control groups suggesting that it is involved in the inflammatory process. PMID: 23317930
    4. phosphorylation of ACAP1 relieves a localized mechanism of autoinhibition in regulating cargo binding PMID: 22645133
    5. the oncogenic potential of USP6 is linked to its ability to integrate cell migration and cytokinesis by regulating Arf6/ACAP1. PMID: 22188517
    6. ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. PMID: 15525538
    7. CENTB1 selectively down-regulates NF-kappaB activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses PMID: 17005562
    8. Results suggest that two ARF6 downstream molecules, PIP5K and ACAP1, function together in endosomal tubulation and that phosphoinositide levels may regulate endosomal dynamics. PMID: 17010122
    9. Results suggest that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings. PMID: 17664335
    10. ACAP1 has robust, constitutive Arf6 GAP activity in vivo, with little activity toward Arf1. PMID: 18003747
    11. Centaurin beta1/KIAA0050, is a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins. Binding of phosphoinositides to a pleckstrin homology domain may regulate subcellular localisation and activity. PMID: 11050434
    12. Centaurin beta1/KIAA0050, or ACAP1, is a phospholipid dependent, ARF6 preferring GTPase-activating protein. It can regulate cytoskeletal and membrane trafficking events in the cell periphery and may be regulated via a phosphoinositide-binding PH domain. PMID: 11062263

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  • 亚细胞定位：
    Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side.
  • 组织特异性：
    Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
  • 数据库链接：

    HGNC: 16467

    OMIM: 607763

    KEGG: hsa:9744

    STRING: 9606.ENSP00000158762

    UniGene: Hs.337242