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Pcsk5 Antibody

  • 货号：
    CSB-PA017644LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Pcsk5 Polyclonal antibody
  • Uniprot No.：
    Q04592
  • 基因名：
    Pcsk5
  • 别名：
    Pcsk5 antibody; Proprotein convertase subtilisin/kexin type 5 antibody; EC 3.4.21.- antibody; Proprotein convertase 5 antibody; PC5 antibody; Proprotein convertase 6 antibody; PC6 antibody; Subtilisin-like proprotein convertase 6 antibody; SPC6 antibody; Subtilisin/kexin-like protease PC5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Proprotein convertase subtilisin/kexin type 5 protein (117-452AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Pcsk5 Antibody (CSB-PA017644LA01MO)，的标记方式是Non-conjugated。对于Pcsk5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA017644LB01MO Pcsk5 Antibody, HRP conjugated ELISA
    FITC CSB-PA017644LC01MO Pcsk5 Antibody, FITC conjugated
    Biotin CSB-PA017644LD01MO Pcsk5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors.
  • 基因功能参考文献：
    1. Pcsk5 may have an essential and early role in the cranio-cardiac mesoderm for heart development. PMID: 28446132
    2. loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. PMID: 28468828
    3. Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. PMID: 21681612
    4. PCSK5 and GDF11 expression during hindgut morphogenesis could be key factors for normal anorectal development, which can be disturbed by the administration of an overdose of all-trans retinoic acid, leading to anorectal malformations. PMID: 21480163
    5. Data suggest that intestinal PC5/6 is protective towards tumorigenesis, especially in mouse duodenum, and possibly in human colon. PMID: 19737405
    6. large cysteine-rich region acts as an important part of functional domain of PC6 PMID: 15122044
    7. PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation PMID: 15601911
    8. the CRD of PC5A and PACE4 functions as a cell surface anchor favoring the processing of their cognate surface-anchored substrates, including endothelial lipase PMID: 16135528
    9. findings show that decidualized differentiation of stroma, which is a prerequisite for embryo implantation, leads to processing of lefty by PC5/6A PMID: 16141390
    10. These results provide the first direct evidence that PC5 is involved in CCK processing PMID: 16266771
    11. These data demonstrate that Pcsk5 is an essential gene. PMID: 16354705
    12. the selectivity of PC5/6 for Gdf11 essentially resides in the presence of a P1' Asn in the RSRR downward arrowN cleavage motif PMID: 18378898
    13. We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. PMID: 18519639
    14. mouse G-cells express PC1/3, 2 and 5/6. we conclude that PC5/6 is without effect on progastrin. PMID: 18554181

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  • 亚细胞定位：
    [Isoform PC5A]: Secreted. Note=Secreted through the regulated secretory pathway.; [Isoform PC5B]: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.
  • 蛋白家族：
    Peptidase S8 family
  • 组织特异性：
    PC5A is expressed in most tissues but is most abundant in the intestine and adrenals. PC5B is expressed in the intestine, adrenals and lung but not in the brain.
  • 数据库链接：

    KEGG: mmu:18552

    STRING: 10090.ENSMUSP00000025618

    UniGene: Mm.3401