Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. PYHIN1 Antibody

PYHIN1 Antibody

  • 货号：
    CSB-PA746957LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PYHIN1 antibody at 6µg/ml + Mouse small intestine tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 56, 55, 52, 51, 27, 26 kDa
      Observed band size: 56, 22, 84 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PYHIN1 Polyclonal antibody
  • Uniprot No.：
    Q6K0P9
  • 基因名：
    PYHIN1
  • 别名：
    IFIX_HUMAN antibody; Interferon-inducible protein X antibody; Pyhin1 antibody; Pyrin and HIN domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Pyrin and HIN domain-containing protein 1 protein (1-245AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PYHIN1 Antibody (CSB-PA746957LA01HU)，的标记方式是Non-conjugated。对于PYHIN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA746957LB01HU PYHIN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA746957LC01HU PYHIN1 Antibody, FITC conjugated
    Biotin CSB-PA746957LD01HU PYHIN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
  • 基因功能参考文献：
    1. Study demonstrates that IFIX antiviral functions work in part via viral transcriptional suppression and that HSV-1 has acquired mechanisms to block its functions via proteasome-dependent degradation. PMID: 28077445
    2. a new member of the hematopoietic interferon (IFN)-inducible nuclear protein. Six different alternatively spliced forms are transcribed from the IFIX gene PMID: 15122330
    3. IFIX alpha1 isoform functions as a tumor suppressor by repressing HDM2 function PMID: 16479015
    4. IFIXalpha suppressed the invasion activity of MDA-MB-468 breast cancer cells, and its inhibitory effect was reversed by the knockdown of maspin PMID: 18247378
  • 亚细胞定位：
    [Isoform 1]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm.; [Isoform 5]: Nucleus. Nucleus speckle.
  • 蛋白家族：
    HIN-200 family
  • 组织特异性：
    Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.
  • 数据库链接：

    HGNC: 28894

    OMIM: 612677

    KEGG: hsa:149628

    STRING: 9606.ENSP00000357122

    UniGene: Hs.710248