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PTPRS Antibody

  • 货号：
    CSB-PA019064GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q13332
  • 基因名：
    PTPRS
  • 别名：
    Protein tyrosine phosphatase PTPsigma antibody; Protein tyrosine phosphatase receptor type S antibody; Protein tyrosine phosphatase receptor type sigma antibody; Ptprs antibody; PTPRS_HUMAN antibody; PTPSIGMA antibody; R PTP sigma antibody; R-PTP-S antibody; R-PTP-sigma antibody; Receptor-type tyrosine-protein phosphatase S antibody; Receptor-type tyrosine-protein phosphatase sigma antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PTPRS
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IP,FC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
  • 基因功能参考文献：
    1. Study identified several CpG sites and specifically several CpGs in the PTPRS and PER3 genes differentially methylated between obese and non-obese children, suggesting a role for DNA methylation concerning development of childhood obesity. PMID: 28614626
    2. interaction of receptor type of protein tyrosine phosphatase sigma (RPTPsigma) with a glycosaminoglycan library PMID: 29420785
    3. Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis. PMID: 25385546
    4. Data demonstrate that synoviocytes are regulated by an RPTPsigma-dependent proteoglycan switch in vivo, which can be targeted for rheumatoid arthritis therapy. PMID: 25995222
    5. represents an evolutionarily conserved pDC-specific inhibitory receptor, and is required to prevent spontaneous IFN production and immune-mediated intestinal inflammation PMID: 26231120
    6. crystallographic analyses of a shared HSPG-CSPG binding site reveal a conformational plasticity that can accommodate diverse glycosaminoglycans with comparable affinities; HS and analogs induced RPTPsigma ectodomain oligomerization which was inhibited by CS PMID: 21454754
    7. Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma. PMID: 22027896
    8. Intragenic microdeletions of the EGFR phosphatase PTPRS were found frequently (26%) in head and neck cancers, identifying this gene as a target of 19p13 loss. PMID: 22065749
    9. Transgenic zebrafish carrying a promoter-driven expression vector reveal the increased density of olfactory sensory neuron-specific cell synapses. PMID: 21812780
    10. Data show that PTPsigma localizes to PtdIns3P-positive membranes in cells, and this vesicular localization is enhanced during autophagy. PMID: 21303930
    11. The receptor protein tyrosine phosphatase sigma (RPTPsigma) has now been identified as a receptor for inhibitory chondroitin sulfate proteoglycans. PMID: 20179269
    12. Transient overexpression of the short splice variant 3 of RPTPR Sigma conferred alpha-LTX induced secretion to hamster insulinoma (HIT-15) cells. In contrast, the long splice variant 2 was inactive in secretion or in a single cell assay. PMID: 16552719
    13. Three SNPs that flank exon 8 are associated with ulcerative colitis. The presence of these SNPs is associated with novel splicing that removes the third immunoglobulin-like domain (exon 9) from the extracellular portion of PTPsigma. PMID: 17614280
    14. SNPs rs1143699, rs4807015, and rs1978237 confer an increased risk of developing type 2 diabetes mellitus. PMID: 17893260
    15. In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency PMID: 19000305

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Cell projection, neuron projection. Cell projection, growth cone.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 2A subfamily
  • 组织特异性：
    Detected in peripheral blood plasmacytoid dendritic cells (at protein level). Detected in all tissues tested except for placenta and liver. Detected in peripheral blood plasmacytoid dendritic cells.
  • 数据库链接：

    HGNC: 9681

    OMIM: 601576

    KEGG: hsa:5802

    STRING: 9606.ENSP00000349932

    UniGene: Hs.744928