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  4. PTPRR Antibody

PTPRR Antibody

  • 货号：
    CSB-PA019063GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q15256
  • 基因名：
  • 别名：
    Ch-1PTPase antibody; Ch1 PTPase antibody; DKFZp781C1038 antibody; EC PTP antibody; ECPTP antibody; FLJ34328 antibody; MGC131968 antibody; MGC148170 antibody; NC PTPCOM1 antibody; NC-PTPCOM1 antibody; Protein tyrosine phosphatase Cr1PTPase precursor antibody; Protein tyrosine phosphatase NC PTPCOM1 antibody; Protein tyrosine phosphatase PCPTP1 antibody; Protein tyrosine phosphatase receptor type R antibody; Protein-tyrosine phosphatase PCPTP1 antibody; PTP SL antibody; PTPBR7 antibody; PTPRQ antibody; PTPRR antibody; PTPRR_HUMAN antibody; PTPSL antibody; R-PTP-R antibody; Receptor type tyrosine protein phosphatase R antibody; Receptor-type tyrosine-protein phosphatase R antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PTPRR
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus.
  • 基因功能参考文献：
    1. The PTPRR genes were related to possible endophenotypes for suicidal behaviour such as anger, depression-anxiety and fatigue. PMID: 28327445
    2. The development of MDD may be related with the polymorphism of ERK-rs12678428 and PTPRR-rs1513105. PMID: 28467119
    3. Results show that PTPRR is an early and direct target of the androgen receptor which negatively regulates the RAS/ERK1/2 pathway suggesting that its loss in prostate cancer cells is one factor that might contribute to activation of the RAS/ERK1/2 pathway. PMID: 25592066
    4. High expression of PTP receptors R and Z1 was observed in all examined cases of colorectal carcinoma, adenoma and normal colon tissue in this study. PMID: 24242166
    5. The methylation index of PTPRR recovered from scrapings of uterine cervix adenocarcinomas is significantly higher than in normal controls. PMID: 24407576
    6. 3 genes identified by association study and supported by ocular expression and/or replication, UHRF1BP1L, PTPRR, and PPFIA2, are novel candidates for myopic development within the MYP3 locus that should be further studied. PMID: 23422819
    7. Methylation of the PTPRR promoter has an important role in the metastasis and may be a biomarker of invasive cervical cancer PMID: 22330137
    8. the protein tyrosine phosphatase receptor type R gene may play a role in conferring risk of major depressive disorder in females PMID: 22100128
    9. expression of the PTPRR-1 isoform was inactivated in colorectal cancer cells as a result of de novo CpG island methylation and enrichment of transcription-repressive histone-tail marks, mainly H3K27me3 PMID: 20015382

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  • 亚细胞定位：
    [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.; [Isoform Gamma]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 7 subfamily
  • 组织特异性：
    Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta,
  • 数据库链接：

    HGNC: 9680

    OMIM: 602853

    KEGG: hsa:5801

    STRING: 9606.ENSP00000283228

    UniGene: Hs.506076