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  4. PTPRM Antibody

PTPRM Antibody

  • 货号：
    CSB-PA166109
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA166109(PTPRM Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA166109(PTPRM Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P28827
  • 基因名：
  • 别名：
    tibody; hR PTPu antibody; Protein tyrosine phosphatase mu antibody; Protein tyrosine phosphatase mu precursor antibody; Protein tyrosine phosphatase receptor type M antibody; Protein tyrosine phosphatase receptor type mu polypeptide antibody; Protein-tyrosine phosphatase mu antibody; PTPRL1 antibody; Ptprm antibody; PTPRM protein antibody; PTPRM_HUMAN antibody; R PTP mu antibody; R-PTP-mu antibody; Receptor type tyrosine protein phosphatase mu antibody; Receptor-type tyrosine-protein phosphatase mu antibody; RPTP mu antibody; RPTPM antibody; RPTPU antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human PTPRM
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
  • 基因功能参考文献：
    1. Study determined that, in addition to the furin-processed form of PTPmicro, a pool of 200 kDa full-length PTPmicro exists at the plasma membrane that is cleaved directly by ADAM to generate a larger shed form of the PTPmicro extracellular segment. PMID: 24771611
    2. Decreased expression of PTPRM in breast cancer is correlated with poor prognosis and inversely correlated with disease-free survival. PMID: 23185569
    3. Loss of PTPmu by proteolysis causes glioblastoma. PMID: 22505657
    4. Results suggest that miR-221 and -222 regulate glioma tumorigenesis at least in part through the control of PTPmu protein expression. PMID: 21743492
    5. In A549 cells, diverse injurious stimuli dramatically reduced PTPmu protein expression. PMID: 21649524
    6. Loss of protein tyrosine phosphatase receptor type mu is associated with glioma cell migration and progression. PMID: 19304959
    7. RPTPmu may play a role in the regulation of cardiovascular functions PMID: 12895029
    8. PTPmu may regulate Rho-GTPase-dependent functions of IQGAP1 PMID: 16380380
    9. a 3.1 angstrom crystal structure of the RPTPmu ectodomain that forms a homophilic trans (antiparallel) dimer with an extended and rigid architecture, matching the dimensions of adherens junctions is described PMID: 17761881
    10. BCCIP is phosphorylated by the Src tyrosine kinase and dephosphorylated by the PTPmu tyrosine phosphatase; neurite outgrowth assays suggest that BCCIP and PTPmu are in a common signal transduction pathway. PMID: 18773424
    11. loss of cell surface PTPmu by proteolysis generates catalytically active PTPmu fragments that contribute to migration and survival of glioblastoma cells PMID: 19690139

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 2B subfamily
  • 数据库链接：

    HGNC: 9675

    OMIM: 176888

    KEGG: hsa:5797

    STRING: 9606.ENSP00000331418

    UniGene: Hs.49774