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  4. PTPRJ Antibody

PTPRJ Antibody

  • 货号：
    CSB-PA005636
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa, 293 cells using CD148 Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q12913
  • 基因名：
  • 别名：
    CD 148 antibody; CD148 antibody; CD148 antigen antibody; Density enhanced phosphatase 1 antibody; Density-enhanced phosphatase 1 antibody; DEP 1 antibody; DEP-1 antibody; HPTP eta antibody; HPTPeta antibody; Human density enhanced phosphatase 1 antibody; Protein tyrosine phosphatase eta antibody; Protein tyrosine phosphatase receptor type J antibody; Protein tyrosine phosphatase receptor type J polypeptide antibody; Protein-tyrosine phosphatase eta antibody; Protein-tyrosine phosphatase receptor type J antibody; PTPJ antibody; Ptprj antibody; PTPRJ_HUMAN antibody; R PTP Eta antibody; R-PTP-eta antibody; R-PTP-J antibody; Receptor type tyrosine protein phosphatase eta antibody; Receptor-type tyrosine-protein phosphatase eta antibody; SCC 1 antibody; SCC1 antibody; susceptibility to colon cancer 1; mouse; homolog of antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CD148.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
  • 基因功能参考文献：
    1. PTPRJ variant of uncertain significance in candidate gene was identified in Familial Mitral Valve Prolapse. PMID: 29762926
    2. Short variant of the receptor protein phosphatase PTPRJ generated by an alternative splicing promotes angiogenesis in HUVEC cells and tumor angiogenesis. PMID: 28052032
    3. study reveals the crucial role of miR-155/PTPRJ/AKT axis in proliferation and migration of colorectal cancer cells and suggests a therapeutic potential of PTPRJ. PMID: 28316102
    4. s demonstrate that mtp53 prevents the COP1/DET1 complex from ubiquitinating ETS2 and thereby marking it for destruction. s show that mtp53 destabilizes DET1 and also disrupts the DET1/ETS2 complex thereby preventing ETS2 degradation. PMID: 26871468
    5. These data support that PTPN22 1858C/T, PTPRJ 2965C/G and 1176 A/C polymorphisms and ACP1 A, B and C alleles are not associated with a higher risk of immune thrombocytopenia P in adults. PMID: 27309885
    6. Loss of PTPRJ expression may predict an aggressive clinical course in ESCC patients. PMID: 26694178
    7. The strongest association with frailty was observed in the Protein Tyrosine Phosphatase, Receptor type, J (PTPRJ) (rs1566729, P = 0.001372, beta = 0.09397) gene. PMID: 26248682
    8. the combination of CD200 and CD148 may have a potential differential diagnostic value in leukemic B-CLPDs, especially between CLL and MCL. PMID: 25791119
    9. These results demonstrated Ptprj as a physiological enzyme that attenuates insulin signalling in vivo, and indicate that an inhibitor of Ptprj may be an insulin-sensitizing agent. PMID: 26063811
    10. CD148 tyrosine phosphatase promotes e-cadherin cell adhesion. PMID: 25386896
    11. The studies suggest induction of MMP-9 expression promoted by DEP-1 deficiency. PMID: 25672645
    12. Moderate expression of DEP-1 was associated with the increased relapse. PMID: 25772245
    13. C33A cells lacking PTPRJ had increased cell viability, growth, migration, G1-S transition, and 5-FU resistance. PTPRJ negatively regulated the JAK1/STAT3 pathway by decreasing phosphorylation levels of JAK1 and STAT3 and expression of downstream factors. PMID: 25634668
    14. The expression profiles of DEP1 and B2MG correlate with increased cell senescence and survival in breast cancer. PMID: 25412306
    15. Phosphorylation of T1318 is part of a regulatory mechanism that channels the activity of DEP-1 towards Src to allow its optimal activation and the promotion of endothelial cell permeability. PMID: 24583284
    16. Data indicate that CD148 is upregulated in macrophages and T cells in rheumatoid arthritis (RA) samples, and its activity is enhanced by treatment with tumour necrosis factor alpha (TNFalpha), and reduced by synovial fluid or oxidising conditions. PMID: 24016860
    17. our data support the notion of DEP-1 as positive functional regulator in vascular cerebral arteriogenesis, involving differential PDGF-B gene expression. PMID: 24027763
    18. FLT3 is a bona fide substrate of DEP-1 and that interaction occurs mainly via an enzyme-substrate complex formation triggered by FLT3 ligand stimulation. PMID: 23650535
    19. haplotypes in PTPRJ gene may play a role in susceptibility to Non-Hodgkin's lymphoma, by affecting activation of PTPRJ in these B-cell lymphomas. PMID: 23341091
    20. Data indicate that miR-328 regulated PTPRJ expression, and suggest that the interaction of miR-328 with PTPRJ is responsible for miR-328-dependent increase of epithelial cell proliferation. PMID: 22564856
    21. These data indicate that PTPRJ may regulate differentiation of normal mammary epithelia and that dysregulation of protein localisation may be associated with tumorigenesis. PMID: 22815804
    22. CD148 polymorphisms affect platelet activation and probably exert a protective effect on the risk of Heparin-induced thrombocytopenia in patients with antibodies to PF4/Heparin complexes. PMID: 22677127
    23. DEP-1 oxidation is a novel event contributing to cell transformation by FLT3 ITD. PMID: 22438257
    24. These findings provide evidence that CD148 functions as a receptor for TSP1 and mediates its inhibition of cell growth. PMID: 22308318
    25. Here the protein tyrosine phosphatase receptor CD148 is shown to be a key intermediary in cell adhesion to S2ED, with downstream beta1 integrin-mediated adhesion and cytoskeletal organization PMID: 21813734
    26. We propose that positive regulation of adhesion signaling by DEP-1 is involved in inhibition of meningioma cell motility, and possibly tumor invasiveness. PMID: 21091576
    27. differential effects of CD148 in T cells and other leukocyte subsets PMID: 21543337
    28. That DEP-1 plays a biologic role in angiogenic endothelial cell behavior was demonstrated in endothelial cell migration, proliferation, and capillary-like tube formation assays in vitro PMID: 21304107
    29. DEP-1 is negatively regulating FLT3 signaling activity and that its loss may contribute to but is not sufficient for leukemogenic cell transformation. PMID: 21262971
    30. Therefore, the results reported here show that the homozygous genotype for Asp872 of PTPRJ is associated with an increased risk to develop papillary thyroid carcinoma. PMID: 20823296
    31. PTPRJ is a candidate colorectal cancer susceptibility gene PMID: 21036128
    32. DEP-1 is a tumor suppressor that dephosphorylates and thereby stabilizes EGFR by hampering its ability to associate with the CBL-GRB2 ubiquitin ligase complex. PMID: 19836242
    33. PTPRJ SNPs were found to influence susceptibility to a wide spectrum of cancers. PMID: 19672627
    34. This protein is frequently deleted in human breast cancers. PMID: 12089527
    35. CD148 and CD27 are expressed in a wide range of B cell non-Hodgkin's lymphomas and do not serve to distinguish between neoplastic cells of naive and memory B cell derivation PMID: 12685844
    36. DEP-1 is a negative regulator of cell proliferation, cell-substratum contacts, motility and chemotaxis in fibroblasts PMID: 14709717
    37. propose that the expression and activation of DEP-1/PTPeta is required for somatostatin inhibition of glioma proliferation PMID: 15123617
    38. A candidate tumor suppressor gene because its expression was blocked in rat and human thyroid transformed cells, and its restoration reverted their neoplastic phenotype. PMID: 15231692
    39. genotypic profile of PTPRJ affects susceptibility to thyroid carcinomas, loss involved in thyroid carcinogenesis PMID: 15378013
    40. single nucleotide polymorphisms in protein tyrosine phosphatase receptor type J is associated with breast cancer PMID: 16000320
    41. Male, dizygotic twins were diagnosed with sensori-neural deafness at ages 5 and 21 months and later developed hypothyroidism at ages 24 and 28 months, respectively. Analysis for anti-DEP-1/CD148 autoantibodies described in Cogan syndrome proved positive. PMID: 16582570
    42. Chemoprotective nutrients elevated transcription of endogenous DEP-1 mRNA & expression of DEP-1 protein. Upregulation of DEP-1 expression & inhibition of cell growth & migration may be a previously unrecognized mechanism of chemoprevention by nutrients. PMID: 16682945
    43. These results demonstrate that CD148 may interact with and dephosphorylate p85 when it is phosphorylated and modulate the magnitude of phosphoinositide 3-kinase activity. PMID: 18348712
    44. The translation of the region between AUG(191) and AUG(356) inhibits the overall expression of PTPRJ mRNA. PMID: 18603590
    45. No significant evidence for the A1176C allele of PTPRJ or previously described haplotypes of tagSNPs in PTPRJ on CRC risk. PMID: 18843023
    46. DEP-1 is a positive regulator of VEGF-mediated Src and Akt activation and endothelial cell survival. PMID: 18936167
    47. The intact structure of the eighth fibronectin domain of PTPRJ is critical for its localization in plasma membrane and biological function. PMID: 19122201
    48. DEP-1 can modify the phosphorylation state of tight junction proteins and play a role in regulating permeability. PMID: 19332538
    49. CD148 may have a role in mantle cell lymphoma PMID: 19413345
    50. In this paper, frequent deletion of PTPRJ is shown in human colon, lung, and breast cancers. PMID: 12089527

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 3 subfamily
  • 组织特异性：
    Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lym
  • 数据库链接：

    HGNC: 9673

    OMIM: 600925

    KEGG: hsa:5795

    STRING: 9606.ENSP00000400010

    UniGene: Hs.318547