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PSPH Antibody

  • 货号：
    CSB-PA018938ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PSPH antibody at 3.81µg/ml
      Lane 1: HL60 whole cell lysate
      Lane 2: A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 25 kDa
      Observed band size: 25 kDa
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA018938ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018938ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PSPH Polyclonal antibody
  • Uniprot No.：
    P78330
  • 基因名：
    PSPH
  • 别名：
    EC 3.1.3.3 antibody; L 3 phosphoserine phosphatase antibody; L-3-phosphoserine phosphatase antibody; O phosphoserine phosphohydrolase antibody; O-phosphoserine phosphohydrolase antibody; Phosphoserine phosphatase antibody; Phosphoserine phosphatase deficiency; included antibody; PSP antibody; PSPase antibody; Psph antibody; PSPHD antibody; SERB_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Phosphoserine phosphatase protein (1-225AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine (Probable).
  • 基因功能参考文献：
    1. PSPH expression is a novel biomarker for poor prognosis and could play an important role in tumor progression of colorectal cancer. PMID: 28476802
    2. We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo PMID: 25793315
    3. study of an intellectual disability family from Pakistan; identified a variant in PSPH: chr7:56088803C>T, NM_004577.3 c.103G>A; p.Ala35Thr (hg19) which segregated in homozygous form with the phenotype in both branches of the family PMID: 25080166
    4. phosphoserine phosphatase deficiency is associated with Neu-Laxova syndrome. PMID: 25152457
    5. status of PSPH in normal skin epidermis and skin tumors along with its sub-cellular localization in epidermal keratinocytes and its requirement for squamous cell carcinoma proliferation PMID: 21726982
    6. purification, crystallization and preliminary X-ray diffraction analysis PMID: 11752790
    7. description of the first crystal structures of the HPSP in complexes with the competitive inhibitor 2-amino-3-phosphonopropionic a PMID: 12213811
    8. human phosphoserine phosphatase structure now shows a sevenfold coordinated Ca(2+) ion in the active site that might explain the inhibitory effect of Ca(2+) on the enzyme PMID: 15291819

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  • 相关疾病：
    Phosphoserine phosphatase deficiency (PSPHD)
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    HAD-like hydrolase superfamily, SerB family
  • 数据库链接：

    HGNC: 9577

    OMIM: 172480

    KEGG: hsa:5723

    STRING: 9606.ENSP00000275605

    UniGene: Hs.512656