PSMD9 Antibody

1. These data suggest that Schistosoma japonicum Sjp40 might inhibit hepatic stellate cell activation by promoting cellular senescence via SKP2/P27 signaling pathway. PMID: 28325896
2. human epidermal growth factor receptor 2 (HER-2) levels, were correlated well with TSP50/p-Samd2/3 and TSP50/p27 expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer PMID: 28650473
3. Furthermore, inhibition of COPS5 resulted in an elevation of Akt expression and sensitized SOC cells to Akt inhibitor MK2206. Suppression of COPS5 and Akt offers a potential strategy for the treatment of SOC. PMID: 28919423
4. Loss of p27 associated with risk for endometrial carcinoma arising in the setting of obesity. PMID: 26917264
5. p53 immunopositivity was more frequent in SCC (65%) than in VC (23%) (P
6. The PSMD9 intronic SNPs rs74421874 (IVS3+nt460 G>A) and rs3825172 (IVS3+nt437 C>T) remain significantly associated with insomnia only when taking into account anxiety -and not depression- as covariate. PMID: 26166263
7. recurrence rate of p27 and/or PTEN-negative patients was higher than that of the positive ones,that should be followed up closely after treatment PMID: 26191286
8. The present study provided the first evidences that miR-1470 mediated lapatinib induced p27 upregulation by targeting c-jun. PMID: 25545366
9. Staining intensities of cell cycle inhibitors p27 and p57 significantly increased in all parts of preeclamptic placentas compared to control PMID: 24852133
10. PSMD9 expression predicts radiotherapy response in breast cancer. PMID: 24673853
11. Expression of Hath1, Muc2, cyclin D1 and p27 in the xenograft tumors was also detected. PMID: 23464457
12. Describe PSMD9 gene SNPs in linkage to generalized anxiety disorder in type 2 diabetic families. PMID: 24648162
13. The PSMD9 single nucleotide polymorphism(SNP)s IVS3+nt460, IVS3+nt437, and 197G are in linkage with overweight condition and waist circumference in Italians. PMID: 23282078
14. Our results suggest that tuberin and p27 are aberrantly expressed in malignant breast tissue PMID: 23689538
15. Surprisingly, we found that GRP/GRP-R differentially induced expressions of p21 and p27. Silencing GRP/GRP-R decreased p21, but it increased p27 expressions in neuroblastoma cells. PMID: 23618860
16. PSMD9 IVS3+nt460 A>G and +nt437 C>T and exon 5 E197G A>G single nucleotide polymorphisms studied and/or any variants in linkage disequilibrium with them are linked to depression in our type 2 diabetes Italian families. PMID: 22934761
17. the PSMD9 IVS3 + nt460, IVS3 + nt437, E197G SNPs are linked via the recessive model to microvascular pathology of type 2 diabetes (T2D) in Italians PMID: 22015693
18. PSMD9 gene SNPs are linked to elevated blood pressure/hypertension in Italian families with type 2 diabetes. PMID: 21871126
19. This study is the first to demonstrate the expression of Bridge-1 in human breast carcinomas. Bridge-1 expression is increased by activin A stimulation and itself seems to influence activin A signaling by affecting the expression of Smad2, 3 and 4. PMID: 21448710
20. overexpression of Jab1, cytoplasmic p27, and pSer10p27 proteins is correlated with poor outcome in patients with glioma PMID: 21837501
21. Brief Report: PSMD9 SNPs show linkage to carpal tunnel syndrome in Italian type 2 diabetics. PMID: 21862167
22. genetic association studies in a population in Italy: SNPs in PSMD9 are strongly linked to diabetic neuropathy in subjects with type 2 diabetes; these associations show significance for an additive model-based inheritance. PMID: 21813292
23. In summary, the PSMD9 IVS3+nt460, IVS3+nt437, E197G SNPs are linked to diabetic retinopathy and non-diabetic retinopathy in Italians. PMID: 21728808
24. Data show that the PSMD9 IVS3 + nt460, IVS3 + nt437, E197G T2D risk SNPs are in linkage with diabetic nephropathy. PMID: 21439668
25. PSMD9 SNPs IVS3 + nt460 A >G, IVS3 + nt437 C > T and E197G A > G are linked to the hypercholesterolemia phenotype in Italian type 2 diabetes families. PMID: 21554682
26. PSMD9 IVS3+nt460A/G, +nt437C/T and exon E197G A/G SNPs are linked to coronary artery disease, stroke/TIA and macrovascular pathology of type 2 diabetes in Italians. PMID: 21496327
27. Analysis of Gem-resistant sub lines also showed that loss of UBE2M and increased p27(Kip1) expression were associated with the acquisition of drug resistance. PMID: 21477582
28. Cul1 regulates melanoma cell growth and cell cycle progression through degradation of p27 PMID: 20878082
29. The expression of p53 and p27 was not related to HPV genotype in cervical carcinomas PMID: 19657726
30. Show that the MODY3 mutation and the PSMD9 IVS3 + nt460A/IVS3 + nt437T/G197 SNPs are risk factors for type 2 diabetes in Italian families. PMID: 20069546
31. Presence is associated with high nuclear grade, large tumor size, and poor prognosis for glioma patients. PMID: 12778072
32. The researchers found evidence of increased positive identification of p27 following neoadjuvant therapy in colorectal cancer patients, p27 was a good predictor of FR in the pre-radiation biopsy, and p27(+) markers in specimens lived longer at 3 years. PMID: 17360176
33. PSMD9 gene variants contribute rarely to late-onset type 2 diabetes in Italians. PMID: 17516568
34. 8679o 78y PMID: 18694622
35. We report a direct correlation between cyclin D3 and p27 expression in gastrointestinal stromal tumors. PMID: 18701138
36. Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting p27 level. PMID: 19041685
37. In RCC, p27 is phosphorylated at T157 of the NLS, with increasing tumor grade associated with cytoplasmic p27. PMID: 19118035
38. PSMD9 gene in the NIDDM2 locus is linked to type 2 diabetes in Italians. PMID: 19877155

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HGNC: 9567

OMIM: 603146

KEGG: hsa:5715

STRING: 9606.ENSP00000440485

UniGene: Hs.131151