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PSMC6 Antibody

  • 货号：
    CSB-PA003865
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of RAW264.7 cells using PSMC6 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P62333
  • 基因名：
    PSMC6
  • 别名：
    26S protease regulatory subunit 10B antibody; 26S protease regulatory subunit S10B antibody; 26S proteasome AAA-ATPase subunit RPT4 antibody; CADP44 antibody; P44 antibody; Proteasome 26S subunit ATPase 6 antibody; Proteasome subunit p42 antibody; PRS10_HUMAN antibody; PSMC6 antibody; Rpt4 antibody; SUG2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PSMC6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
  • 基因功能参考文献：
    1. Evidence of a sex-specific association of PSMC6 genetic variants with subtypes of juvenile idiopathic arthritis. PMID: 24875235
    2. Advanced oxidation protein products down-regulate the expression of calcium transport channels through p44/42 MAPK signaling mechanisms in the small intestinal epithelium. PMID: 25801217
    3. N protein of SARS Coronavirus interacts with the host cell proteasome subunit p42. PMID: 20478047
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    AAA ATPase family
  • 数据库链接：

    HGNC: 9553

    OMIM: 602708

    KEGG: hsa:5706

    STRING: 9606.ENSP00000401802

    UniGene: Hs.156171