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PSMC4 Antibody

  • 货号：
    CSB-PA018894GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P43686
  • 基因名：
    PSMC4
  • 别名：
    26S protease regulatory subunit 6B antibody; 26S proteasome AAA ATPase subunit RPT3 antibody; 26S proteasome AAA-ATPase subunit RPT3 antibody; MB67 interacting protein antibody; MB67-interacting protein antibody; MIP224 antibody; Protease 26S subunit 6 antibody; Proteasome (prosome macropain) 26S subunit ATPase 4 antibody; Proteasome 19S S6 antibody; Proteasome 26S subunit ATPase 4 antibody; Proteasome 26S subunit; ATPase; 4 antibody; PRS6B_HUMAN antibody; PSMC4 antibody; RPT3 antibody; S6 antibody; Tat binding protein 7 antibody; TAT-binding protein 7 antibody; TBP 7 antibody; TBP-7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PSMC4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
  • 基因功能参考文献：
    1. This study demonstrated that particular distribution for HSC70 and PSMC4 in the cytoplasm and accumulation within Lewy body in the dopaminergic neurons of the substantia nigra in Parkinson patients. PMID: 29218503
    2. Structural mechanism for nucleotide-driven remodeling of RPT3 and its homologs in the activated human 26S proteasome has been reported. PMID: 29636472
    3. Site-specific Rpt3 phosphorylation by DYRK2 controls cell proliferation and tumorigenesis in breast neoplasms. PMID: 26655835
    4. Saquinavir-NO inhibits activation of S6 protein in androgen-dependent prostate cancer cells. PMID: 22370480
    5. The proposed TRAP1 network has an impact in vivo, as it is conserved in human colorectal cancers, is controlled by ER-localized TRAP1 interacting with TBP7 and provides a novel model of the ER-mitochondria crosstalk. PMID: 21979464
    6. C terminus of Rpt3, an ATPase subunit of PA700 (19 S) regulatory complex, is essential for 26 S proteasome assembly but not for activation PMID: 20937828
    7. interacts with gankyrin through C-terminal 78 amino acids PMID: 11779854
    8. a novel specific interaction of synphilin-1 with the regulatory proteasomal protein S6 ATPase (tbp7) in aggresome-like intracytoplasmic inclusions PMID: 17327361
    9. An insertion/deletion variant in intron 5 of the S6 ATPase gene was more frequent in German Parkinson's disease patients compared to controls PMID: 18446261

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    AAA ATPase family
  • 数据库链接：

    HGNC: 9551

    OMIM: 602707

    KEGG: hsa:5704

    STRING: 9606.ENSP00000157812

    UniGene: Hs.211594