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PSMC3IP Antibody

  • 货号：
    CSB-PA018892GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9P2W1
  • 基因名：
    PSMC3IP
  • 别名：
    PSMC3IP antibody; HOP2 antibody; TBPIP antibody; Homologous-pairing protein 2 homolog antibody; Nuclear receptor coactivator GT198 antibody; PSMC3-interacting protein antibody; Proteasome 26S ATPase subunit 3-interacting protein antibody; Tat-binding protein 1-interacting protein antibody; TBP-1-interacting protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PSMC3IP
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.
  • 基因功能参考文献：
    1. The PSMC3IP mutation provides additional evidence that mutations in meiotic homologous recombination and DNA repair genes result in distinct female and male reproductive phenotypes, including delayed puberty and primary amenorrhea caused by Primary ovarian insufficiency (XX gonadal dysgenesis) in females but isolated azoospermia with normal pubertal development in males. PMID: 29240891
    2. PSMC3IP gene mutations are not common causes of primary ovarian insufficiency in this Swedish cohort. PMID: 24481226
    3. GT198 mutant luteinized theca cells overexpressing CYP17 are common in ovarian cancer stroma. PMID: 24097974
    4. a PSMC3IP/HOP2 mutation may cause XX ovarian dysgenesis through abolishing coactivation of estrogen-driven transcription PMID: 21963259
    5. Data suggest that the human TBPIP/Hop2-Mnd1 complex may ensure proper pairing between homologous chromosomes through its stimulation of strand exchange during meiosis [Hop2]. PMID: 16407260
    6. Data suggest that the human TBPIP/Hop2-Mnd1 complex may ensure proper pairing between homologous chromosomes through its stimulation of strand exchange during meiosis. PMID: 16407260
    7. findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP. PMID: 19325002
    8. Identification of GT198 (TBPIP/Hop2) as a nuclear receptor coactivator. GT198 is phosphorylation regulated. GT198 interacts with nuclear receptors. PMID: 11739747

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  • 相关疾病：
    Ovarian dysgenesis 3 (ODG3)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HOP2 family
  • 组织特异性：
    Highly expressed in testis and colon.
  • 数据库链接：

    HGNC: 17928

    OMIM: 608665

    KEGG: hsa:29893

    STRING: 9606.ENSP00000377384

    UniGene: Hs.383019