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PSMC3 Antibody

  • 货号：
    CSB-PA018891LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA018891LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA018891LA01HU at dilution of 1:100
    • Immunofluorescence staining of A549 cells with CSB-PA018891LA01HU at 1:530, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PSMC3 Polyclonal antibody
  • Uniprot No.：
    P17980
  • 基因名：
    PSMC3
  • 别名：
    26S protease regulatory subunit 6A antibody; 26S proteasome AAA-ATPase subunit RPT5 antibody; Human immunodeficiency virus tat transactivator binding protein 1 antibody; MGC8487 antibody; Proteasome (prosome macropain) 26S subunit ATPase 3 antibody; Proteasome 26S ATPase subunit 3 antibody; Proteasome 26S subunit ATPase 3 antibody; Proteasome subunit P50 antibody; PRS6A_HUMAN antibody; PSMC 3 antibody; PSMC3 antibody; Tat binding protein 1 antibody; TAT-binding protein 1 antibody; TBP-1 antibody; TBP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human 26S proteasome regulatory subunit 6A protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PSMC3 Antibody (CSB-PA018891LA01HU)，的标记方式是Non-conjugated。对于PSMC3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018891LB01HU PSMC3 Antibody, HRP conjugated ELISA
    FITC CSB-PA018891LC01HU PSMC3 Antibody, FITC conjugated
    Biotin CSB-PA018891LD01HU PSMC3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
  • 基因功能参考文献：
    1. These data suggest the existence of a negative feedback loop involving Akt/PKB that might act as a sensor to modulate TBP-1 levels in proliferating cells. PMID: 21991300
    2. 19S ATPase S6b (S6'/TBP1) binds CIITApIV in an S6a-dependent fashion and has effects similar to S6a on CIITApIV histone acetylation. PMID: 19853614
    3. role in E3 ubiquitin ligase function of the von Hippel-Lindau protein PMID: 14556007
    4. molecular modeling of DNA:TATA element binding protein (TBP) interactions after treatment with 2-Chloro-2'-deoxyadenosine PMID: 14610662
    5. Tat-binding protein-1 binds to human ARF tumor suppressor and has a role in control of cell proliferation PMID: 14665636
    6. In normal cells, unmodified S12 associates with the 26S proteasome, while modified S12-M does not. PMID: 15221960
    7. The stabilization effect exerted by TBP-1 requires an intact N-terminal 39 amino acids in ARF and occurs independently from N-terminal ubiquitination of the protein. PMID: 17334400
    8. Heplipin induced KG-1 cell apoptosis is related with Wntl3 and ATPase3. PMID: 17649721
    9. findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP. PMID: 19325002

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    AAA ATPase family
  • 数据库链接：

    HGNC: 9549

    OMIM: 186852

    KEGG: hsa:5702

    STRING: 9606.ENSP00000298852

    UniGene: Hs.250758