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PSMC1 Antibody

  • 货号：
    CSB-PA123862
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA123862(PSMC1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA123862(PSMC1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA123862(PSMC1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P62191
  • 基因名：
    PSMC1
  • 别名：
    26S protease regulatory subunit 4 antibody; 26S proteasome AAA-ATPase subunit RPT2 antibody; MGC24583 antibody; MGC8541 antibody; P26s4 antibody; p56 antibody; protease 26S, subunit 4 antibody; Proteasome (prosome macropain) 26S subunit ATPase 1 antibody; Proteasome 26S ATPase subunit 1 antibody; Proteasome 26S subunit ATPase 1 antibody; PRS4_HUMAN antibody; PSMC 1 antibody; Psmc1 antibody; S4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human PSMC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
  • 基因功能参考文献：
    1. P26s4 Associates with the C-Terminal Region of TOPORS. PMID: 26872363
    2. Our results suggest that there is no association between variations or haplotypes in the PSMC1 gene and Parkinson's disease PMID: 22948515
    3. Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity PMID: 20424172
    4. Hepatocytes dying because of inhibition of proteasome function produce massive quantities of the proinflammatory chemokine IL-8, possibly resulting in neutrophil infiltration, increased inflammation, and liver injury. PMID: 14578856
    5. Psmc1 conditional knock-out mice demonstrate that 26S proteasomal dysfunction is sufficient to trigger neurodegenerative disease. PMID: 18701681

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Membrane; Lipid-anchor.
  • 蛋白家族：
    AAA ATPase family
  • 数据库链接：

    HGNC: 9547

    OMIM: 602706

    KEGG: hsa:5700

    STRING: 9606.ENSP00000261303

    UniGene: Hs.356654