Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. PSMB1 Antibody

PSMB1 Antibody

  • 货号：
    CSB-PA018876GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P20618
  • 基因名：
    PSMB1
  • 别名：
    FLJ25321 antibody; HC5 antibody; KIAA1838 antibody; Macropain subunit C5 antibody; Multicatalytic endopeptidase complex subunit C5 antibody; Proteasome (prosome macropain) subunit beta type 1 antibody; Proteasome beta 1 subunit antibody; Proteasome component C5 antibody; Proteasome gamma chain antibody; Proteasome subunit beta type 1 antibody; Proteasome subunit beta type-1 antibody; Proteasome subunit HC5 antibody; PSB1_HUMAN antibody; PSC5 antibody; PSMB 1 antibody; PSMB1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PSMB1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
  • 基因功能参考文献：
    1. In vitro analyses demonstrated significantly reduced protease activity in proteasomes of individuals with G/G genotype compared with that of C/C carriers, despite that PSMB1 expression and proteasome assembly remained unaltered. PMID: 28733196
    2. The proteasome beta1 subunit plays a novel role in tumorigenesis by degrading p27Kip1. PMID: 23725357
    3. The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes. PMID: 23924720
    4. The proteasome was found to be activated in primary sjogren syndrome, with upregulation of gene expression of catalytic proteasome subunits. PMID: 23504381
    5. Follicular lymphoma patients with PSMB1 P11A (G allele) and low CD68 expression have significantly longer progression free survival with bortezomib-rituximab versus rituximab. PMID: 23549871
    6. PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1. PMID: 23544109
    7. Expression of 26S proteasome beta(1)-subunit in NB4 cells increased after incubation with As(2)O(3). PMID: 19549367
    8. data defined a unique motif of BCL-3 that is needed for its recruitment to the proteasome and identified PSMB1 as a key protein required for the proteasome-mediated degradation of a nuclear and oncogenic IkappaB protein. PMID: 20558726

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1B family
  • 数据库链接：

    HGNC: 9537

    OMIM: 602017

    KEGG: hsa:5689

    STRING: 9606.ENSP00000262193

    UniGene: Hs.352768