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PSMA3 Antibody

  • 货号：
    CSB-PA018867LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, PC-3 whole cell lysate, NIH/3T3 whole cell lysate, Hela whole cell lysate, Rat lung tissue, Mouse liver tissue
      All lanes: PSMA3 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 29, 28 kDa
      Observed band size: 29 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018867LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA018867LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PSMA3 Polyclonal antibody
  • Uniprot No.：
    P25788
  • 基因名：
    PSMA3
  • 别名：
    HC8 antibody; Macropain subunit C8 antibody; MGC12306 antibody; MGC32631 antibody; Multicatalytic endopeptidase complex subunit C8 antibody; Proteasome (prosome macropain) subunit alpha type 3 antibody; Proteasome alpha 3 subunit antibody; Proteasome component C8 antibody; Proteasome subunit alpha type 3 antibody; Proteasome subunit alpha type-3 antibody; Proteasome subunit C8 antibody; PSA3_HUMAN antibody; PSC8 antibody; psmA3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Proteasome subunit alpha type-3 protein (218-248AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PSMA3 Antibody (CSB-PA018867LA01HU)，的标记方式是Non-conjugated。对于PSMA3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018867LB01HU PSMA3 Antibody, HRP conjugated ELISA
    FITC CSB-PA018867LC01HU PSMA3 Antibody, FITC conjugated
    Biotin CSB-PA018867LD01HU PSMA3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
  • 基因功能参考文献：
    1. High PSMA3 expression is associated with cholangiocarcinoma. PMID: 28560424
    2. Our results provide evidence on new T1DM-susceptible loci in the PSMA3, PSMA6 and PSMC6 proteasome genes and give a new insight into the T1DM pathogenesis PMID: 26661414
    3. Evidence of a sex-specific association of PSMA3 genetic variants with subtypes of juvenile idiopathic arthritis. PMID: 24875235
    4. Protein interaction between Ambn and Psma3 can facilitate redistribution of ameloblastin domains within forming enamel. PMID: 26070558
    5. A combination of two-dimensional gel electrophoresis (2D-GE) and tandem mass-spectrometry revealed a large number of PSMA3-bound proteins that are involved in various aspects of mRNA metabolism, including splicing. PMID: 22079093
    6. Serum 20S proteasome concentration and percentage of lymphocytic apoptosis predicted survival and patient prognosis in critically ill patients. PMID: 21108816
    7. Plasminogen activator inhibitor type 1 interacts with alpha3 subunit of proteasome and modulates its activity. PMID: 21135093
    8. Aurora-B might undergo degradation by binding to HC8 in a proteasome-dependent manner during mitosis PMID: 14674694
    9. EBNA3C binds to human the C8/alpha7 subunit of the 20S proteasome; degraded by purified 20S proteasomes in vitro but, found to be very stable and apparently turned over at a very low rate in B cells infected latently with EBV PMID: 15831937
    10. The s propose that the full-length HCV F protein as well as the F protein initiating from codon 26 is degraded by an ubiquitin-independent pathway that is mediated by the proteasome subunit alpha3. PMID: 18971267

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1A family
  • 数据库链接：

    HGNC: 9532

    OMIM: 176843

    KEGG: hsa:5684

    STRING: 9606.ENSP00000216455

    UniGene: Hs.558799