Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. PRR5 Antibody

PRR5 Antibody

  • 货号：
    CSB-PA977660
  • 规格：
    ￥1100
  • 图片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human normal kidney tissue, Primary antibody: CSB-PA977660(PRR5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P85299
  • 基因名：
  • 别名：
    Arhgap8 antibody; AU043908 antibody; C030017C09Rik antibody; C78947 antibody; FLJ20185 antibody; FLJ20185k antibody; MGC109513 antibody; MGC32512 antibody; PP610 antibody; Proline rich 5 (renal) antibody; Proline-rich protein 5 antibody; Protein observed with Rictor-1 antibody; Protor-1 antibody; PROTOR1 antibody; PRR5 antibody; PRR5_HUMAN antibody; PTOR1 antibody; Rho GTPase activating protein 8 antibody; RP1-181C9.3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human PRR5
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
  • 基因功能参考文献：
    1. Fusion protein PRR5-ARHGAP8 plays a role in bipolar disorder with binge eating behavior. PMID: 29391396
    2. mRNA expression analyses revealed PRR5 overexpression in a majority of colorectal tumors but substantial downregulation of PRR5 expression in a subset of breast tumors and reduced expression in two breast cancer cell lines PMID: 15718101
    3. It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 results in the co-immunoprecipitation of other mTORC2 subunits, but not Raptor, a specific component of mTORC1. PMID: 17461779
    4. The inhibition of Akt and S6K1 phosphorylation by PRR5 knock down correlates with reduction in the expression level of platelet-derived growth factor receptor beta (PDGFRbeta). PMID: 17599906
  • 蛋白家族：
    PROTOR family
  • 组织特异性：
    Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors.
  • 数据库链接：

    HGNC: 31682

    OMIM: 609406

    KEGG: hsa:55615

    STRING: 9606.ENSP00000384848

    UniGene: Hs.102336