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PRR11 Antibody

  • 货号：
    CSB-PA836225LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA836225LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA836225LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA836225LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Mouse heart tissue
      All lanes: PRR11 antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 41 kDa
      Observed band size: 41 kDa
  • 其他：

产品详情

  • 产品描述：

    The PRR11 antibody (CSB-PA836225LA01HU) is produced in the rabbit with a peptide corresponding to amino acids 1-360 of the human PRR11 immunized. This polyclonal antibody occurs as an unconjugated IgG. Its purity is 95%+ using protein G purified. It is reactive with human and mouse samples. The PRR11 protein, a newly identified oncogene related to a poor prognosis in several human cancers, exerts multiple biological effects, including the modulation of cell cycle and promotion of cellular migration and invasion. This anti-PRR11 antibody has been quality-verified in ELISA, WB, IHC, and IF applications.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PRR11 Polyclonal antibody
  • Uniprot No.：
    Q96HE9
  • 基因名：
    PRR11
  • 别名：
    FLJ11029 antibody; Homo sapiens proline rich 11 antibody; Proline rich protein 11 antibody; Proline-rich protein 11 antibody; PRR 11 antibody; Prr11 antibody; PRR11_HUMAN antibody; transcription repressor of MHCII antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Proline-rich protein 11 protein (1-360AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PRR11 Antibody (CSB-PA836225LA01HU)，的标记方式是Non-conjugated。对于PRR11 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836225LB01HU PRR11 Antibody, HRP conjugated ELISA
    FITC CSB-PA836225LC01HU PRR11 Antibody, FITC conjugated
    Biotin CSB-PA836225LD01HU PRR11 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a critical role in cell cycle progression.
  • 基因功能参考文献：
    1. PRR11 plays an oncogenic role in hepatocellular carcinoma (HCC) progression, through activating the Wnt/beta-catenin signaling pathway, and may represent a valuable prognostic marker and therapeutic target for HCC. PMID: 30248355
    2. PRR11 positively regulated cell proliferation-related proteins, including c-myc and cyclin D1, and increased and decreased the expression of matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 and PRR11 expression was mediated by the phosphoinositide 3-kinase/AKT/beta-catenin signaling pathway. PMID: 30165366
    3. these findings further illustrate the suppressive role of miR-195 in prostate cancer (PCa), and indicate a novel role of PRR11 in PCa. Importantly, the newly identified miR-195/PRR11 axis may aid with identifying potential therapeutic targets in PCa. PMID: 29393495
    4. PRR11 regulated self-renewal and tumorigenicity of gastric cancer stem cells through MAPK signaling, and could be used as a therapeutic target for gastric cancer. PMID: 30007956
    5. these findings indicated that miR-144-3p induced cell cycle arrest and apoptosis in pancreatic cancer by targeting PRR11. PMID: 28574724
    6. p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. PMID: 28257042
    7. Microarray analysis revealed that several genes involved in cell proliferation, cell adhesion, and cell migration were altered in PRR11-knockout cells. PMID: 25971332
    8. PRR11 may be widely activated in human gastric cancer. PMID: 26252227
    9. Targeted depletion of PRR11 caused a dramatic cell cycle arrest followed by massive apoptotic cell death, and eventually resulted in a significant decrease in growth and viability in lung cancer cell lines. PMID: 25973065
    10. PRR11-SKA2 bidirectional transcription unit, which is a novel direct target of NF-Y, is essential for the accelerated proliferation and motility of lung cancer cells PMID: 26162986
    11. Overexpression of PRR11 inhibits cell proliferation and induces premature chromatin condensation. PMID: 25666944
    12. our results strongly demonstrated that this newly identified gene, PRR11, had a critical role in both cell cycle progression and tumorigenesis, and might serve as a novel potential target in the diagnosis and/or treatment of human lung cancer. PMID: 23246489
    13. the apparent occurrence of an unusual TG 3' splice site in intron 10 is discussed PMID: 17672918

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 25619

    OMIM: 615920

    KEGG: hsa:55771

    STRING: 9606.ENSP00000262293

    UniGene: Hs.631750