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PRPF6 Antibody

  • 货号：
    CSB-PA008476
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O94906
  • 基因名：
    PRPF6
  • 别名：
    Androgen receptor N terminal domain transactivating protein 1 antibody; ANT 1 antibody; ANT1 antibody; C20orf14 antibody; hPrp6 antibody; p102 U5 small nuclear ribonucleoprotein particle binding protein antibody; pre-mRNA processing factor 6 antibody; Pre-mRNA-processing factor 6 antibody; PRP6 homolog antibody; PRP6 pre mRNA processing factor 6 homolog antibody; PRP6_HUMAN antibody; PRPF6 antibody; Putative mitochondrial outer membrane protein import receptor antibody; TOM antibody; U5 snRNP-associated 102 kDa protein antibody; U5-102 kDa protein antibody; U5-102K antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human PRP6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
  • 基因功能参考文献：
    1. an essential role for PRPF6 in cancer via splicing of distinct growth-related gene products. PMID: 24788092
    2. Our results identify PRPF6 as the sixth gene involved in pre-mRNA splicing and dominant RP, corroborating the hypothesis that deficiencies in the spliceosome play an important role in the molecular pathology of this disease. PMID: 21549338
    3. The s provide evidence that PRP6 and PRP31 are directly phosphorylated by human PRP4 kinase (PRP4K) concomitant with their incorporation into B complexes. PMID: 20118938
    4. identification as a coactivator for the androgen receptor [p102 U5 small nuclear ribonucleoprotein particle-binding protein] PMID: 12039962
    5. The interaction of CD2BP2 with a tri-snRNP bridging protein (Prp6), coupled with CD2BP2's absence from the tri-snRNP, suggests it might function in tri-snRNP assembly PMID: 15840814
    6. C20orf14 may have a role in progression of lymphoma PMID: 18278469

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  • 相关疾病：
    Retinitis pigmentosa 60 (RP60)
  • 亚细胞定位：
    Nucleus, nucleoplasm. Nucleus speckle.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 15860

    OMIM: 613979

    KEGG: hsa:24148

    STRING: 9606.ENSP00000266079

    UniGene: Hs.31334