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PRPF40A Antibody

  • 货号：
    CSB-PA018769LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: U251 whole cell lysate, Hela whole cell lysate, 293T whole cell lysate
      All lanes: PRPF40A antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 109, 106, 107, 11 kDa
      Observed band size: 109 kDa
    • IHC image of CSB-PA018769LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PRPF40A Polyclonal antibody
  • Uniprot No.：
    O75400
  • 基因名：
    PRPF40A
  • 别名：
    Fas ligand associated factor 1 antibody; Fas ligand-associated factor 1 antibody; FBP 11 antibody; FBP11 antibody; FLAF 1 antibody; FLAF1 antibody; FNBP 3 antibody; Formin binding protein 11 antibody; Formin binding protein 3 antibody; Formin-binding protein 11 antibody; Formin-binding protein 3 antibody; HIP-10 antibody; HIP10 antibody; Huntingtin interacting protein A antibody; Huntingtin interacting protein HYPA antibody; Huntingtin yeast partner A antibody; Huntingtin-interacting protein 10 antibody; Huntingtin-interacting protein A antibody; HYPA antibody; NY REN 6 antibody; NY REN 6 antigen antibody; PR40A_HUMAN antibody; Pre mRNA processing factor 40 homolog A antibody; Pre-mRNA-processing factor 40 homolog A antibody; PRP40 pre mRNA processing factor 40 homolog A (S cerevisiae) antibody; PRP40 pre mRNA processing factor 40 homolog A (yeast) antibody; PRP40 pre mRNA processing factor 40 homolog A antibody; PRPF 40A antibody; PRPF40A antibody; Renal carcinoma antigen NY-REN-6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pre-mRNA-processing factor 40 homolog A protein (120-266AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PRPF40A Antibody (CSB-PA018769LA01HU)，的标记方式是Non-conjugated。对于PRPF40A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018769LB01HU PRPF40A Antibody, HRP conjugated ELISA
    FITC CSB-PA018769LC01HU PRPF40A Antibody, FITC conjugated
    Biotin CSB-PA018769LD01HU PRPF40A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.
  • 基因功能参考文献：
    1. our data revealed that COL1A1, UCP2, and PRPF40A are novel players implicated in the complex network of hypoxia response in non-small cell lung cancer PMID: 28258342
    2. Multidisciplinary approach showed that HsPrp40Ap interacts with centrin in vitro, supporting a coupled functional role for these proteins in pre-mRNA splicing. PMID: 28636910
    3. Study of native domain FF3-71 from human HYPA/FBP11 and the truncated version FF3-60 with C-terminal helix being deleted by molecular dynamics simulations. PMID: 22408419
    4. Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA). PMID: 21566141
    5. an atomic-resolution structure of an "invisible" folding intermediate of a small protein module: the FF domain; structure reveals non-native elements preventing formation of native conformation in the carboxyl-terminal part of the protein PMID: 20829478
    6. Data describe the structure of an FF domain from HYPA/FBP11, which differs from those of other phosphopeptide-binding domains and represents a novel phosphopeptide-binding fold. PMID: 12381297
    7. Results suggest an essential role of WW/FF domain-containing factors such as FBP11 and CA150 in pre-mRNA splicing that likely occurs in concert with transcription in vivo. PMID: 15456888
    8. NAKAP-HypA scaffold is a potential nuclear docking site for huntingtin protein and may contribute to the nuclear accumulation of huntingtin observed in HD. PMID: 16391387
    9. FBP11 binding mechanism underlies the molecular pathology of severe neurological disorders, e.g., Rett syndrome and Huntington disease. PMID: 17065151

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  • 亚细胞定位：
    Nucleus speckle. Nucleus matrix.
  • 蛋白家族：
    PRPF40 family
  • 组织特异性：
    Expressed in the brain cortex (at protein level). Widely expressed.
  • 数据库链接：

    HGNC: 16463

    OMIM: 612941

    KEGG: hsa:55660

    STRING: 9606.ENSP00000386458

    UniGene: Hs.643580