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PROX1 Antibody

  • 货号：
    CSB-PA298119
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from A431 cells using Prospero homeobox protein 1 Antibody and the same antibody preincubated with blocking peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PROX1 Polyclonal antibody
  • Uniprot No.：
    Q92786
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Peptide sequence around aa.723~727 (E-I-F-K-S) derived from Human Prospero homeobox protein 1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • 基因功能参考文献：
    1. PROX1 expression was detected in gastric cancer tissues at various levels. PROX1 expression levels were positively correlated with cancer stage, N factor, lymphatic vascular invasion, and vascular invasion in patients with gastric cancer. PMID: 30396930
    2. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to lymph endothelial cells retraction. PMID: 29749465
    3. Prox1 is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1. PMID: 27731315
    4. PROX1 is a new prognostic biomarker for 1p19q non-codeleted high-grade astrocytomas that have progressed from pre-existing low-grade tumors and harbor IDH mutations. PMID: 27626492
    5. ERbeta in both normal and cancerous colon epithelial cells upregulates miRNA-205, which subsequently reduces PROX1 through direct interaction with its 3'UTR PMID: 27283988
    6. The aim of this study was to examine the association between HHEX (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .Despite these associations, PROX1 gene variants were not previously examined in women with GDM; however, our results suggest a lack of such an association. PMID: 27684496
    7. PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response. PMID: 27476001
    8. crucial promoter of hepatocellular carcinoma angiogenesis PMID: 28646551
    9. study achieved a long-lasting expression of Prox1 in lymphatic endothelial-like cells, and it provided a potentially useful approach for developing novel therapies for limb lymphedema and lymphatic system-related diseases PMID: 28055225
    10. In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis. PMID: 28854215
    11. High PROX1 and beta-catenin expression were independent factors for better prognosis in pancreatic ductal adenocarcinoma. PMID: 27411302
    12. Data suggest that DBC1 has a dual function in regulating beta-catenin-PROX1 signaling axis: as a coactivator for both beta-catenin and PROX1. PMID: 26477307
    13. PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity. PMID: 28060188
    14. We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant PMID: 28453575
    15. PROX1 serves an oncogenic role in glioblastoma multiforme and promotes cell proliferation and invasiveness potentially via activation of the NFkappa B signaling pathway. PMID: 28035380
    16. High PROX1 expression is associated with gastric cancer. PMID: 26759228
    17. High PROX1 expression is associated with Esophageal Squamous Cell Carcinoma. PMID: 26310281
    18. Reduced expression of Prox1 is beneficial for the expansion and maturation of beta-cells. PMID: 26631740
    19. PROX1 is an important regulator of endocrine secretory granule formation in medullary thyroid cancer cells. PMID: 26760117
    20. Findings demonstrate that NOTCH-induced PROX1 inactivation significantly promotes the malignant behavior of thyroid carcinoma. PMID: 26609053
    21. These results suggest that the hepatic functions of the human iPS-HLCs could be enhanced by ATF5, c/EBPalpha, and PROX1 transduction. PMID: 26679606
    22. In primary lymphatic endothelial cells (HDLEC), miR-466 mimic transfection suppressed Prox1 mRNA and protein expression. HDLEC transfected with the miR-466 mimic suppressed tube formation as compared to the scrambled control. PMID: 25573115
    23. Increase in PROX1 expression renders HCC cells more resistant to sorafenib treatment. PMID: 25684142
    24. Our results indicate that immunohistochemical detection of PROX1 correlates with a more malignant phenotype in rectal neuroendocrine tumors PMID: 26063416
    25. PROX1 target genes and show that repression of a pro-apoptotic member of the BCL2 family, BCL2L15, is important for survival of PROX1(+) cells under metabolic stress. PMID: 25242332
    26. Prox1 regulates PDPN expression at the transcriptional level in the lymphatic vascular system PMID: 24944097
    27. retina. These results confirm the conservative functions of Prox1/PROX1 in the vertebrate retina PMID: 25735162
    28. PROX1 functions as a tumor suppressor gene in oral carcinogenesis. PMID: 25526434
    29. These data suggest that PROX1 SNP rs340874 may be a pharmacogenetic risk factor for antihypertensive-induced hyperglycemia PMID: 24122840
    30. expression of Prox-1 in the neoplastic spindle cells supports the view of a lymphatic differentiation in oral Kaposi's sarcoma and it may also be involved in the pathogenesis of oral Kaposi's sarcoma. PMID: 23763431
    31. Our powerful strategic analysis enabled the discovery of a novel candidate gene, PROX1, associated with Waist circumference in an Asian population. PMID: 23818313
    32. Results suggested that Prox1 and FOXC2 play key roles in OSCC progression and that further studies focusing on these proteins may yield useful insights for diagnosis and therapy of OSCC. PMID: 24647631
    33. PDGFRB is one of the key mediators of lymphatic vessel formation acting downstream of Prox1. PMID: 24981766
    34. PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1alpha expression and protein stability. PMID: 23505027
    35. Prox1 interacts with LSD1 to recruit the repressive LSD1/NuRD complex to CYP7A1 promoter and co-represses transcription through epigenetic mechanisms. PMID: 23626788
    36. Single Nucleotide Polymorphism in PROX1 gene is associated with type 2 diabetes. PMID: 22992776
    37. COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1 PMID: 23345397
    38. The present study aimed to find whether PROX1 is expressed in small cell lung cancer (SCLC) cell lines, and whether PROX1 knockdown with shRNA via lentivirus resulted in decreased cell proliferation. PMID: 23898075
    39. The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype. PMID: 23291986
    40. Prox1 strongly suppresses the proliferation of mouse and human neuroblastoma cell lines and blocks the growth of neuroblastoma tumors in SCID mice. PMID: 22508481
    41. genetic association studies in adolescent populations in Europe: Data suggest that 3 SNPs in PROX1 (rs340838; rs340837; rs340836) are associated with fasting plasma insulin levels and may play a role in regulation of insulin secretion. PMID: 23274905
    42. PROX1 promotes epithelial-mesenchymal transition and colon cancer progression. PMID: 23045246
    43. Prox1 gene transcription is regulated by HIF-1alpha and HIF-2alpha in hypoxia. PMID: 23395615
    44. The presence of Prox1 nuclear expression was detected starting from CIN2 and CIN3 lesions to microinvasive carcinoma, in the nuclei of lymphatic and venous endothelial cells and scattered stromal cells. PMID: 23059885
    45. PROX1 directly binds to proximal promoter of TWIST1 gene to repress its transcription PMID: 22982861
    46. The only nominal association with diabetes incidence was found for the glucose-lowering allele at PROX1 (P = 0.02), in a direction opposite to that reported in case-control analyses in MAGIC. PMID: 22984506
    47. we report that IL3 receptor alpha (IL3Ralpha) and NOTCH play integral roles in the host cell type-specific regulation of PROX1 by Kaposi sarcoma herpes virus PMID: 22719258
    48. High PROX1 expression is associated with neuroblastomas. PMID: 22382784
    49. Prox1 is a direct upstream modifier of Nkx2.5 by maintaining the adult conduction system and rescue of Nkx2.5 conduction disease phenotypes. PMID: 22647876
    50. Prox1 expression in hemangiomas and angiosarcoma may be diagnostically useful and offer a new parameter in the biological classification of vascular tumors. PMID: 22067331

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Prospero homeodomain family
  • 组织特异性：
    Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 9459

    OMIM: 601546

    KEGG: hsa:5629

    STRING: 9606.ENSP00000261454

    UniGene: Hs.741808