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PRMT8 Antibody

  • 货号：
    CSB-PA018737GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NR22
  • 基因名：
    PRMT8
  • 别名：
    ANM8_HUMAN antibody; Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 4 antibody; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 antibody; HMT1 hnRNP methyltransferase like 3 antibody; HMT1 hnRNP methyltransferase like 4 antibody; HRMT1 L3 antibody; HRMT1 L4 antibody; HRMT1L 3 antibody; HRMT1L 4 antibody; HRMT1L3 antibody; HRMT1L4 antibody; prmt8 antibody; Protein arginine N methyltransferase 4 antibody; Protein arginine N methyltransferase 8 antibody; Protein arginine N-methyltransferase 8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PRMT8
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer. Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS.
  • 基因功能参考文献：
    1. PRMT8 in human embryonic stem cells plays an important role not only in maintaining pluripotency but also in controlling mesodermal differentiation. PMID: 28543863
    2. Biochemical, biophysical and mutagenesis experiments demonstrated that hPRMT8 forms an octamer in solution. PMID: 26876602
    3. Mutational defects in PRMT8 is not the cause of frontotemporal lobar degeneration. PMID: 23635657
    4. automethylation of the N terminus likely regulates PRMT8 activity by decreasing the affinity of the enzyme for AdoMet PMID: 23946480
    5. wild type FUS (FUS-WT) specifically interacts with protein arginine methyltransferases 1 and 8 (PRMT1 and PRMT8) and undergoes asymmetric dimethylation PMID: 23620769
    6. PRMT8 is an active arginine methyltransferase that is membrane-associated and tissue-specific PMID: 16051612
    7. PRMT8 N-terminal domain may function as an autoregulator that may be displaced by interaction with one or more physiological inducers. PMID: 17925405
    8. The interaction between PRMT8 and the EWS protein was charcterized. PMID: 18320585
    9. EWS is a substrate for PRMT8, as efficient as for PRMT1 PMID: 18698489

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family, PRMT8 subfamily
  • 组织特异性：
    Brain-specific.
  • 数据库链接：

    HGNC: 5188

    OMIM: 610086

    KEGG: hsa:56341

    STRING: 9606.ENSP00000372067

    UniGene: Hs.504530