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PRDM16 Antibody

  • 货号：
    CSB-PA872534LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA872534LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA872534LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：
    兔抗人 (PRDM16) 多克隆抗体是一种转录因子，在各种发育过程中起着关键作用，包括脂肪生成、肌生成和造血作用。重组人 PRDM16 蛋白 (448-683AA) 是指使用重组 DNA 技术生产的 PRDM16 蛋白的特定部分。
     
    PRDM16 蛋白的 448-683AA 区域包含部分 PR 结构域，它参与蛋白质-蛋白质相互作用和组蛋白甲基转移酶活性，以及​​几个对 DNA 结合很重要的锌指结构域。该蛋白质区域被认为对其作为转录因子的功能很重要。
     
    重组人PRDM16蛋白（448-683AA）可用于各种研究应用，例如研究PRDM16蛋白的结构和功能，研究PRDM16在各种发育过程中的作用，以及开发与PRDM16功能障碍相关的疾病的新疗法。生产的 PRDM16 蛋白的特定部分。
     
    PRDM16 蛋白的 448-683AA 区域包含部分 PR 结构域，它参与蛋白质-蛋白质相互作用和组蛋白甲基转移酶活性，以及​​几个对 DNA 结合很重要的锌指结构域。该蛋白质区域被认为对其作为转录因子的功能很重要。
     
    重组人PRDM16蛋白（448-683AA）可用于各种研究应用，例如研究PRDM16蛋白的结构和功能，研究PRDM16在各种发育过程中的作用，以及开发与PRDM16功能障碍相关的疾病的新疗法。
  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PRDM16 Polyclonal antibody
  • Uniprot No.：
    Q9HAZ2
  • 基因名：
    PRDM16
  • 别名：
    CMD1LL antibody; KIAA1675 antibody; LVNC8 antibody; MDS1/EVI1 like gene 1 antibody; MDS1/EVI1-like gene 1 antibody; MEL1 antibody; PFM 13 antibody; PFM13 antibody; PR domain containing 16 antibody; PR domain containing protein 16 antibody; PR domain zinc finger protein 16 antibody; PR domain-containing protein 16 antibody; PRD16_HUMAN antibody; Prdm16 antibody; Transcription factor MEL 1 antibody; Transcription factor MEL1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human PR domain zinc finger protein 16 protein (448-683AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PRDM16 Antibody (CSB-PA872534LA01HU)，的标记方式是Non-conjugated。对于PRDM16 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA872534LB01HU PRDM16 Antibody, HRP conjugated ELISA
    FITC CSB-PA872534LC01HU PRDM16 Antibody, FITC conjugated
    Biotin CSB-PA872534LD01HU PRDM16 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions as a repressor of TGF-beta signaling.; Binds DNA and functions as a transcriptional regulator. Functions as a repressor of TGF-beta signaling. May regulate granulocyte differentiation.
  • 基因功能参考文献：
    1. Study revealed that LINC00982 and PRDM16 may serve as biomarkers or potential drug targets for the diagnosis and therapy of lung adenocarcinoma. PMID: 30132554
    2. Multiple regression analysis showed that age, male gender, body max index, presence of obesity, type-2-diabetes mellitus, hypertension and coronary artery disease and left ventricular ejection fraction were associated with the expression levels of UCP1, PGC1alpha and PRDM16 mRNA PMID: 28824327
    3. Our study suggests that the MEF2D, PRDM16 and ASTN2 genes from GWAS are associated with migraine susceptibility, especially migraine without aura , among Chinese patients. It appears that there is no association with serotonin receptor related genes. PMID: 28058730
    4. High PRDM16 expression is a significant predictive marker for poor prognosis in adult AML patients. PMID: 28710806
    5. Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT. PMID: 28701693
    6. Flow cytometric analysis and western blot analysis of apoptosisassociated proteins indicated that PRDM16 has an antiapoptotic role in prostatic cancer cells. In addition, the spliced form, sPRDM16/MEL1S, was detected to be overexpressed in PCa cell lines. In conclusion, the present study indicated an important oncogenic role in prostate cancer. PMID: 27511603
    7. A single risk variant, rs2651899 in PRDM16, was significantly associated with efficacy of triptans in migraine patients PMID: 26502740
    8. High PRDM16 expression is associated with astrocytoma. PMID: 26701852
    9. Our results suggest that K568 SUMOylation of sPRDM16 plays an important role in the progression of acute myeloid leukemia. PMID: 26559765
    10. Results show that PRDM16 overexpression was highly recurrent in de novo paediatric AML and is associated with adverse outcome PMID: 26684393
    11. PRDM16 might contribute to maintain adipose tissue "white fat" gene expression profile and systemic metabolic homeostasis. PMID: 25662275
    12. EVI1 and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations have roles in Japanese pediatric acute myeloid leukemia PMID: 25567132
    13. Three novel loci were identified in East Asians with cardiac arrhythmias: rs2483280 (PRDM16 locus) and rs335206 (PRDM6 locus) were associated with QRS duration; and rs17026156 (SLC8A1 locus) correlated with PR interval. PMID: 25035420
    14. Genetic analyses uncovered the importance of the PRDM16 gene in the regulation of lean body mass. PMID: 24863034
    15. MED1 is required for optimal PRDM16-induced Ucp1 expression PMID: 25644605
    16. PRDM2, PRDM5, PRDM16 promoters are methylated and their expression is suppressed in lung cancer cells. PMID: 24966940
    17. Mutations in gene encoding the transcriptional co-activator PRDM16 may be a cause of left-ventricular noncompaction and dilated cardiomyopathy. PMID: 24717670
    18. The rs2651899 variant in PRDM16 plays a role in Chinese common migraine susceptibility. PMID: 24021092
    19. An association between PRDM16 rs2651899 SNP and migraine in a Swedish case-control study. PMID: 24674449
    20. No association between the four polymorphisms of the PRDM16 gene with essential hypertension. PMID: 24327154
    21. Single nucleotide polymorphism Rs2236518 is associated with body mass index in the young Chinese males (using QTDT), and the older Chinese males (using GLM-ANOVA). PMID: 23524569
    22. Mutation of PRDM16 causes the cardiomyopathy in 1p36 deletion syndrome as well as a proportion of nonsyndromic left ventricular noncompaction cardiomyopathy and dilated cardiomyopathy. PMID: 23768516
    23. High PRDM16 expression is associated with pheochromocytoma. PMID: 23454374
    24. Data identify Prdm3 and Prdm16 as H3K9me1 methyltransferases and expose a functional framework in which anchoring to the nuclear periphery helps maintain the integrity of mammalian heterochromatin. PMID: 22939622
    25. genetic association studies in a Chinese Xinjiang Uygur population: Studies suggest that commonly occurring SNP in PRDM16 (rs2236518) shows a significant negative association with metabolic syndrome in a multivariable logistic regression analysis. PMID: 22383139
    26. Survival data suggest that patients with AML/MDS and PRDM16 translocations have a poor prognosis despite a simple karyotype and a median age of 65 years. PMID: 22050763
    27. genome-wide association studies have successfully identified four new genetic variants associated with migraine in the LRP1, TRPM8, and PRDM16 genes PMID: 22072275
    28. Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus PMID: 22039459
    29. Breakpoints occurring in the first intron and in the 5' region of the MEL1 gene associated with the t(1;3)(p36;q21) translocation have been found in three myelodysplastic syndrome/acute myelogenous leukemia patients. PMID: 12557231
    30. structure, expression pattern, and function of MEL1 in leukemia cells; overexpression of the zinc finger protein lacking the PR domain (EVI1 and MEL1S)is likely one of the causative factors in the pathogenesis of myeloid leukemia. PMID: 12816872
    31. Aberrant gene expression associated with DNA hypomethylation is implicated in leukemogenesis of adult T-cell leukemia. PMID: 14656887
    32. Correction opf X-linked chronic granulomatous disease by gene therapy was augmented by insertional activation of PRDM16. PMID: 16582916
    33. A 3' RACE experiments followed by sequence-specific RT-PCR resulted in the identification of the PRDM16 gene as a novel fusion partner of the RUNX1 gene in a patient with rare t(1;21)(p36;q22). PMID: 16598304
    34. RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL+ leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance PMID: 18202228
    35. array CGH performed on CD34(+) cells revealed cryptic partial deletions of PRDM16. PMID: 18767145
    36. SKI and MEL1 knockdown synergistically restored TGF-beta responsiveness in MKN28 cells and reduced tumor growth in vivo PMID: 19049980
    37. PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown adipocytes. PMID: 19285866
    38. PRDM16 and PGC-1 alpha expression was 2-fold greater in epicardial than sc fat. PMID: 19567523
    39. data indicate that the PRDM16-C/EBP-beta complex initiates brown fat formation from myoblastic precursors PMID: 19641492

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  • 相关疾病：
    Left ventricular non-compaction 8 (LVNC8); Cardiomyopathy, dilated 1LL (CMD1LL)
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells.
  • 数据库链接：

    HGNC: 14000

    OMIM: 605557

    KEGG: hsa:63976

    STRING: 9606.ENSP00000270722

    UniGene: Hs.99500