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PRAF2 Antibody

  • 货号：
    CSB-PA003847
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of RAT-HEART cells using PRAF2 Polyclonal Antibody
    • Western Blot analysis of Jurkat NIH-3T3 cells using PRAF2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O60831
  • 基因名：
    PRAF2
  • 别名：
    PRAF2; JM4; PRA1 family protein 2
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human PRAF2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis.
  • 基因功能参考文献：
    1. PRAF2 plays an essential role in neuroblastoma tumorigenesis and metastasis. PMID: 23440329
    2. Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells PMID: 21203533
    3. PRAF2 expression is elevated in various tumors with exceptionally high expression in malignant gliomas, and may thus presents a candidate molecular target for therapeutic intervention. PMID: 20412121
    4. PRAF2 (JM4) is CCR5-interacting protein, which is suggested to function in trafficking and membrane localisation of the receptor. PMID: 15757671
    5. CCR5-interacting PRAF2 protein is expressed in several human tissues with a possible function in ER/Golgi transport and vesicular traffic. PMID: 16481131
    6. PRAF2 has a role in progression of neuroblastoma PMID: 17975142
    7. The expression of PRAF2 in specific regions of the brain including SVs suggest an important physiological function for this novel protein, possibly by participating in multiple aspects of SV maturation, transport, and signal transmission. PMID: 18395978

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  • 亚细胞定位：
    Endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PRA1 family
  • 组织特异性：
    Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly
  • 数据库链接：

    HGNC: 28911

    OMIM: 300840

    KEGG: hsa:11230

    STRING: 9606.ENSP00000365570

    UniGene: Hs.29595