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PPP6R3 Antibody

  • 货号：
    CSB-PA020701GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q5H9R7
  • 基因名：
    PPP6R3
  • 别名：
    C11orf23 antibody; Chromosome 11 open reading frame 23 antibody; KIAA1558 antibody; PP6R3 antibody; PP6R3_HUMAN antibody; PPP6R3 antibody; Protein phosphatase 6 regulatory subunit 3 antibody; SAP190 antibody; SAPL antibody; SAPLa antibody; SAPS domain family member 3 antibody; SAPS domain family; member 3 antibody; Serine/threonine-protein phosphatase 6 regulatory subunit 3 antibody; Sporulation induced transcript 4 associated protein SAPL antibody; Sporulation-induced transcript 4-associated protein SAPL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SAPS3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance.
  • 基因功能参考文献：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that PPP6R3 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. we found a DPP9-PPP6R3 fusion transcript in one tumor showing a matching genomic 11;19-translocation. Another tumor had a rearrangement of DPP9 with PLIN3. Both rearrangements were associated with diminished expression of the 3' end of DPP9 corresponding to the breakpoints identified by RNA-seq. PMID: 28893231
    3. Molecular analyses revealed the presence and amplification of the novel PPPR6-USP6 gene fusion, which resulted in USP6 mRNA transcriptional upregulation. These findings further support the oncogenic role of the USP6 protease in mesenchymal neoplasia and expand the biologic potential of Nodular fasciitis PMID: 27113271
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    SAPS family
  • 组织特异性：
    Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes.
  • 数据库链接：

    HGNC: 1173

    OMIM: 610879

    KEGG: hsa:55291

    STRING: 9606.ENSP00000377390

    UniGene: Hs.503022