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PPP4C Antibody

  • 货号：
    CSB-PA018577GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P60510
  • 基因名：
  • 别名：
    PP X antibody; PP-X antibody; Pp4 antibody; PP4C antibody; PP4C_HUMAN antibody; PPH3 antibody; PPP4 antibody; ppp4c antibody; PPX antibody; protein phosphatase 4 (formerly X), catalytic subunit antibody; Protein phosphatase 4 catalytic subunit antibody; Protein phosphatase X antibody; protein phosphatase X, catalytic subunit antibody; Serine/threonine protein phosphatase 4 catalytic subunit antibody; Serine/threonine-protein phosphatase 4 catalytic subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PPP4C
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
  • 基因功能参考文献：
    1. PP4 regulates breast cancer cell survival and identifies a novel PP4c-PEA15 signalling axis in the control of breast cancer cell survival. PMID: 27317964
    2. Data show that protein phosphatase 4 catalytic subunit (PP4C) knockdown decreases glioma cell proliferation. PMID: 27059736
    3. mutual regulatory mechanisms exist between PP4 and SAF-A. Interactions between PP4 and SAF-A played a role in prometaphase/metaphase transition. PMID: 27041735
    4. These data suggested a potential role of PP4C in tumor progression. PMID: 25927939
    5. Stathmin plays an essential role of in Merkel cell polyomavirus small tumor antigen-mediated microtubule destabilization and cell motility and this process is regulated by cellular phosphatase catalytic subunit of protein phosphatase 4. PMID: 25320307
    6. PP4 and Wip1 are differentially required to counteract the p53-dependent cell cycle arrest in G1 and G2, by antagonizing early or late p53-mediated responses, respectively PMID: 24711418
    7. Results show PP4C as a fostriecin-sensitive phosphatase and demonstrate that the suppression of PP4C triggers mitotic slippage/apoptosis. PMID: 23671329
    8. Data indicate that the major phosphatase responsible for dephosphorylation of of BAF Ser-4 to be protein phosphatase 4 catalytic subunit. PMID: 24265311
    9. Recombinant gamma-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A in vitro. PMID: 23966160
    10. PP4c is a key regulator of cortical development that changes the orientation of progenitor division responsible for the transition between symmetric and asymmetric cell division. PMID: 23830831
    11. Overexpression of PP4C is associated with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma. PMID: 22665577
    12. PP4R1 and PP4c Cooperate to Catalyze IKK Dephosphorylation PMID: 23084358
    13. PP4C and KAP1 are in the same epistasis group, and PP4 is involved in NHEJ-mediated DSB repair, possibly through regulating the phosphorylation status of KAP1. PMID: 22732494
    14. The s devised a novel proteomic strategy for systematic identification of proteins dephosphorylated by PP4C and identified KRAB-domain-associated protein 1 (KAP-1) as a substrate. PMID: 22491012
    15. PP4R2, a regulatory subunit of PP4, mediates the DNA damage-dependent association between RPA2 and the PP4C catalytic subunit. PMID: 20154705
    16. Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs PMID: 12668731
    17. protein phosphatase 4 has a role in NF-kappaB p65 Thr dephosphorylation PMID: 15073167
    18. IRS-4 is subject to regulation by TNF-alpha, and PP4 mediates TNF-alpha-induced degradation of IRS-4 PMID: 15331607
    19. PP4 is a positive regulator for HPK1 and the HPK1-JNK signaling pathway PMID: 15364934
    20. Our work uncovers a unique regulatory mechanism of MT organization by PP4c through its targets Cdk1 and NDEL1 via regulation of katanin p60 distribution. PMID: 18347064
    21. Analysis of the role of the serine/threonine protein phosphatase, protein phosphatase 4, in controlling the apoptosis of HEK 293 T cells, using the complementary techniques of gene over-expression and down regulation through RNA interference. PMID: 18424272
    22. The results suggest that Ppp4c-R2-R3 complexes may co-ordinate centrosome maturation and cell migration via regulation of RhoGTPases. PMID: 18487071
    23. A three-protein PP4 phosphatase complex in mammalian cells, containing PP4C, PP4R2, and PP4R3beta, specifically dephosphorylates ATR-mediated gamma-H2AX generated during DNA replication. PMID: 18614045
    24. PP4R4 forms a novel cytosolic complex with PP4c, independent from the complexes containing PP4R1, PP4R2.PP4R3, and alpha4, and the regulatory subunits of PP4c have evolved different modes of interaction with the catalytic subunit PMID: 18715871
    25. An evolutionarily conserved gamma histone 2AX phosphatase active on both DNA-damaged and undamaged chromatin. PMID: 18758438
    26. PP4 activity significantly affects the mutation rate in leukemic T-cells, indicating that PP4 dysfunction may be important in the development and progression of leukemia PMID: 19539371

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    PPP phosphatase family, PP-4 (PP-X) subfamily
  • 数据库链接：

    HGNC: 9319

    OMIM: 602035

    KEGG: hsa:5531

    STRING: 9606.ENSP00000279387

    UniGene: Hs.534338