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PPP3R1 Antibody

  • 货号：
    CSB-PA018575GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P63098
  • 基因名：
  • 别名：
    alpha isoform (calcineurin B; type I) antibody; calcineurin B; type I (19kDa) antibody; Calcineurin subunit B type 1 antibody; CALNB1 antibody; CANB1_HUMAN antibody; Cna2 antibody; CNB antibody; CNB1 antibody; OTTHUMP00000201960 antibody; OTTHUMP00000201961 antibody; Ppp3r1 antibody; PPP3R1 protein phosphatase 3 (formerly 2B); regulatory subunit B; alpha isoform antibody; protein phosphatase3 (formerly2B); regulatory subunit B; alpha isoform antibody; Protein phosphatase 2B regulatory subunit 1 antibody; Protein phosphatase 2B regulatory subunit B alpha antibody; protein phosphatase 3 (formerly 2B); regulatory subunit B; 19kDa; alpha isoform (calcineurin B; type I) antibody; Protein phosphatase 3 (formerly 2B); regulatory subunit B (19kD); alpha isoform (calcineurin B; type I) antibody; Protein phosphatase 3 regulatory subunit B alpha antibody; Protein phosphatase 3 regulatory subunit B alpha isoform 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PPP3R1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
  • 基因功能参考文献：
    1. expression of PPP3R1 decreased respectively in psoriatic lesions and HaCaT cells. PMID: 29181737
    2. The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels. PMID: 28827117
    3. we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4/MD2 complex together with the co-receptor CD14 PMID: 27090571
    4. CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 signaling through TRAF3 and TRAF6, in response to various agonists. PMID: 26471241
    5. Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B. PMID: 24246042
    6. Further evidence that specific variations in MAPT (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease PMID: 23727081
    7. Expression level of PPP3R1 and GATA4, and NFATC4 genes for transcription factors did not differ in studied subgroups of patients. PMID: 23888774
    8. Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT targets required for replication, insulin storage, and secretion. PMID: 22814600
    9. These findings reveal a novel signaling pathway (CnB-CD11b-NF-kappaB-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity. PMID: 22197822
    10. immunostimulatory protein and acts as a vaccine adjuvant inducing protective cellular and humoral responses against pneumococcal infection PMID: 21722668
    11. CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells. PMID: 21910968
    12. CNB binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of hypoxia-inducible factor-1alpha (HIF-1alpha) via the proteasome pathway. PMID: 21256111
    13. these data imply novel functions of calcineurin and NF-kappaB for successful IS maturation. PMID: 17038582
    14. Endothelin 1 (ET-1) activates calcineurin and causes nuclear translocation of NFATc1, implicating the pathway in the ET-1-mediated stimulation of osteoblasts. PMID: 17237284
    15. IGF-1/PPP3R1 gene polymorphisms influence muscle phenotypic responses to strength training in both black and white older men and women. PMID: 17761791
    16. No significant differences in calcineurin b expression was observed between patients with schizophrenia and normal controls PMID: 18343007
    17. Overexpression of calcineurin B subunit enhances the oncogenic potential of HEK293 cells PMID: 18422742
    18. Study found that although calcineurin/NFAT signalling pathway has an important, non-redundant role in the regulation of lymphocyte developmental checkpoints, it is not essential for the development of blood myeloid lineages. PMID: 18818667
    19. CNB gene 5I/5D polymorphism is associated with the risk of left ventricular hypertrophy and physical performance of athletes. PMID: 18825932

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cell membrane. Cell membrane, sarcolemma. Cell membrane; Lipid-anchor.
  • 蛋白家族：
    Calcineurin regulatory subunit family
  • 数据库链接：

    HGNC: 9317

    OMIM: 601302

    KEGG: hsa:5534

    STRING: 9606.ENSP00000234310

    UniGene: Hs.280604