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PPP3CC Antibody

  • 货号：
    CSB-PA018574ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform antibody at 8μg/ml
      Lane 1: Rat brain tissue
      Lane 2: MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 59, 58, 60 kDa
      Observed band size: 59 kDa
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA018574ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA018574ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPP3CC Polyclonal antibody
  • Uniprot No.：
    P48454
  • 基因名：
  • 别名：
    calcineurin A gamma antibody; CALCINEURIN A3 antibody; Calcineurin antibody; Calcineurin testis specific catalytic subunit antibody; Calmodulin dependent calcineurin A subunit gamma isoform antibody; Calmodulin-dependent calcineurin A subunit gamma isoform antibody; CALNA3 antibody; CAM PRP catalytic subunit antibody; CAM-PRP catalytic subunit antibody; CNA3 antibody; pp2b gamma Antibody antibody; PP2BC_HUMAN antibody; PP2Bgamma Antibody antibody; PPP3CC antibody; protein phosphatase 3 (formerly 2B) catalytic subunit gamma isoform (calcineurin A gamma) antibody; protein phosphatase 3 (formerly 2B) catalytic subunit gamma isoform antibody; Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform antibody; testis-specific catalytic subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform protein (373-512AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
  • 基因功能参考文献：
    1. PPP3CC rs7431 may alter miRNA binding ability of miR-212 and miR-132, and thus decrease bladder cancer risk. PMID: 29275364
    2. These findings indicated that the down-regulation of PPP3CC by ZEB1 resulted in activation of NF-kappaB is a critical oncogenic event in gliomas. PMID: 29294030
    3. The rs2443504 AA genotype was associated with the Glasgow coma score at 3, 6, and 12 months following severe brain injury. PMID: 27225880
    4. Knockdown of CNAgamma leads to a disruption of synaptic vesicle cycling in hippocampal neurons. PMID: 26627835
    5. The PPP3CC involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation. PMID: 24709691
    6. protein level of PPP3CC negatively correlates with the cellular level of IP3, suggesting a regulatory role of PPP3CC in the IP3-Ca2+ signaling pathway PMID: 23747857
    7. study suggests that NMDA receptor-mediated signalling genes, DAO, PPP3CC, DTNBP1 might be involved in schizophrenia pathogenic mechanisms related to gender PMID: 23497497
    8. This study demoistrated that PPP3CC are not genetic risk factors for schizophrenia in japanese. PMID: 20537399
    9. results identify PPP3CC, located at 8p21.3, as a potential schizophrenia susceptibility gene and support the proposal that alterations in calcineurin signaling contribute to schizophrenia pathogenesis PMID: 12851458
    10. Decreased hippocampal expression of the susceptibility gene PPP3CC in schizophrenia. PMID: 15820226
    11. PPP3CC may not play a major role in Japanese schizophrenia PMID: 15843870
    12. The results suggest that PPP3CC gene may be a true susceptibility gene for schizophrenia. PMID: 17339875
    13. The Polymorphism, Single Nucleotide of ppp3cc is assosciated with schizophrenia. PMID: 17895921
    14. No significant differences in calcineurin A gamma expression was observed between patients with schizophrenia and normal controls PMID: 18343007
    15. Data suggest that PPP3CC does not elevate the risk of methamphetamine-use disorder in the Japanese population. PMID: 18991849

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  • 蛋白家族：
    PPP phosphatase family, PP-2B subfamily
  • 组织特异性：
    Testis.
  • 数据库链接：

    HGNC: 9316

    OMIM: 114107

    KEGG: hsa:5533

    STRING: 9606.ENSP00000240139

    UniGene: Hs.731683