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PPP1R3B Antibody

  • 中文名称：
    PPP1R3B兔多克隆抗体
  • 货号：
    CSB-PA769802LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PPP1R3B antibody at 6µg/ml + Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 33 kDa
      Observed band size: 33 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA769802LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA769802LA01HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: Rat heart tissue
      All lanes: PPP1R3B antibody at 2.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 33 kDa
      Observed band size: 33 kDa
  • 其他：

产品详情

  • 产品描述：

    The PPP1R3B polyclonal antibody is produced in rabbits using recombinant human protein phosphatase 1 regulatory subunit 3B protein (1-285aa) as an immunogen. Protein G affinity chromatography was used to purify the antibody, achieving a purity level exceeding 95%, ensuring high quality and freedom from impurities that may interfere with experimental results.

    This PPP1R3B antibody is capable of detecting PPP1R3B protein in human, mouse, and rat samples. It has been extensively tested in various applications, including ELISA, WB, and IHC, for the qualitative and quantitative detection of PPP1R3B protein, as well as the determination of the presence and size and detection of localization and expression levels of this protein.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPP1R3B Polyclonal antibody
  • Uniprot No.：
    Q86XI6
  • 基因名：
  • 别名：
    FLJ14005 antibody; FLJ34675 antibody; GL antibody; Hepatic glycogen targeting protein phosphatase 1 regulatory subunit GL antibody; Hepatic glycogen targeting subunit G(L) antibody; Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL antibody; PP1 subunit R4 antibody; Ppp1r3b antibody; PPP1R4 antibody; PPR3B_HUMAN antibody; Protein phosphatase 1 regulatory (inhibitor) subunit 3B antibody; Protein phosphatase 1 regulatory subunit 3B antibody; Protein phosphatase 1 regulatory subunit 4 antibody; Protein phosphatase 1 subunit 4 antibody; Protein phosphatase 1 subunit GL antibody; PTG antibody; R4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Protein phosphatase 1 regulatory subunit 3B protein (1-285AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PPP1R3B Antibody (CSB-PA769802LA01HU)，的标记方式是Non-conjugated。对于PPP1R3B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA769802LB01HU PPP1R3B Antibody, HRP conjugated ELISA
    FITC CSB-PA769802LC01HU PPP1R3B Antibody, FITC conjugated
    Biotin CSB-PA769802LD01HU PPP1R3B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
  • 基因功能参考文献：
    1. These observations are consistent with the notion that the minor allele of rs4841132 promotes a mild form of hepatic glycogenosis that is associated with hepatic injury PMID: 29266543
    2. rs9987289 A-allele was associated with plasma lactate in European-Americans but not in African-Americans. PMID: 26433129
    3. Among Mexicans, the PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), and GCKR (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults. PMID: 27752939
    4. A novel role for PTG in protecting hepatocellular carcinoma cells from metabolic stress, in part by regulating oxidative stress and autophagy. PMID: 26182369
    5. Some, but not all, associations between variants in NCAN, lysophospholipase-like 1, GCKR, and PPP1R3B with hepatic steatosis (with and without increased ALT level) were significant within subpopulations. PMID: 23416328
    6. Data indicate that genetic polymorphisms of the PPP1R3B gene may contribute to variations in plasma lipids and C-reactive protein (CRP) levels among Chinese Han individuals. PMID: 23343124
    7. Results suggest that in cultured human myotubes, glycogen-targeting PP1 (protein phosphatase 1) subunit G(L) (coded for by the PPP1R3B gene) is expressed as in muscle tissue and is unresponsive to glucose or insulin, as are G(M) and PTG genes. PMID: 17555403

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  • 组织特异性：
    Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expr
  • 数据库链接：

    HGNC: 14942

    OMIM: 610541

    KEGG: hsa:79660

    STRING: 9606.ENSP00000308318

    UniGene: Hs.458513