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PPP1R11 Antibody

  • 货号：
    CSB-PA03834A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA03834A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPP1R11 Polyclonal antibody
  • Uniprot No.：
    O60927
  • 基因名：
    PPP1R11
  • 别名：
    PPP1R11 antibody; HCGV antibody; TCTE5 antibody; E3 ubiquitin-protein ligase PPP1R11 antibody; EC 2.3.2.27 antibody; Hemochromatosis candidate gene V protein antibody; HCG V antibody; Protein phosphatase 1 regulatory subunit 11 antibody; Protein phosphatase inhibitor 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase PPP1R11 protein (1-126AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PPP1R11 Antibody (CSB-PA03834A0Rb)，的标记方式是Non-conjugated。对于PPP1R11 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA03834B0Rb PPP1R11 Antibody, HRP conjugated ELISA
    FITC CSB-PA03834C0Rb PPP1R11 Antibody, FITC conjugated
    Biotin CSB-PA03834D0Rb PPP1R11 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
  • 基因功能参考文献：
    1. Lentiviral gene transfer or knockdown of PPP1R11 in mouse lungs significantly affects lung inflammation and the clearance of Staphylococcus aureus. There is a negative correlation between PPP1R11 and TLR2 levels in white blood cell samples isolated from patients with Staphylococcus aureus infections PMID: 27805901
    2. a model in which I3 regulates an SDS22-mediated PP1 activation step in solution that precedes SDS22 dissociation and transfer of PP1 to kinetochores, and which is required for PP1 to efficiently antagonize Aurora B. PMID: 25298395
    3. Sds22 and Inhibitor-3 form a heterotrimeric complex with PP1, both in cell lysates and after purification. A pool of PP1 is complexly controlled by both Sds22 and Inhibitor-3. PMID: 17630778
    4. inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response PMID: 18450750
    5. Inh3 has two domains that are required for its interaction with PP1. PMID: 18951879

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  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 9285

    OMIM: 606670

    KEGG: hsa:6992

    STRING: 9606.ENSP00000365963

    UniGene: Hs.82887