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PPM1L Antibody

  • 货号：
    CSB-PA018498GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q5SGD2
  • 基因名：
    PPM1L
  • 别名：
    PPM1L antibody; PP2CE antibody; Protein phosphatase 1L antibody; EC 3.1.3.16 antibody; Protein phosphatase 1-like antibody; Protein phosphatase 2C isoform epsilon antibody; PP2C-epsilon antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PPM1L
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
  • 基因功能参考文献：
    1. Genetic variation at chromosome 3 harbors an element that regulates expression of an upstream candidate tumor suppressor, PPM1L, thus providing a novel mechanism for colorectal tumorigenesis. PMID: 19847890
    2. cloning and characterization of a novel human protein phosphatase 2C cDNA (PP2C epsilon*) PMID: 15560375
    3. These results suggest that PP2Cepsilon maintains ASK1 in an inactive state by dephosphorylation in quiescent cells, supporting the possibility that PP2Cepsilon and PP5 play different roles in H2O2-induced regulation of ASK1 activity. PMID: 17456047
    4. CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus. PMID: 18165232
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    PP2C family
  • 组织特异性：
    Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.
  • 数据库链接：

    HGNC: 16381

    OMIM: 611931

    KEGG: hsa:151742

    STRING: 9606.ENSP00000417659

    UniGene: Hs.389027