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PPM1B Antibody

  • 货号：
    CSB-PA018490GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O75688
  • 基因名：
  • 别名：
    MGC21657 antibody; OTTHUMP00000158953 antibody; OTTHUMP00000158954 antibody; OTTHUMP00000158955 antibody; OTTHUMP00000202394 antibody; OTTHUMP00000202395 antibody; OTTHUMP00000202399 antibody; PP2C beta antibody; PP2C beta X antibody; PP2C-beta antibody; PP2CB antibody; PP2Cbeta antibody; PPC2BETAX antibody; PPM 1B antibody; Ppm1b antibody; PPM1B_HUMAN antibody; Protein phosphatase 1B (formerly 2C) magnesium dependent beta isoform antibody; Protein phosphatase 1B antibody; Protein phosphatase 1B magnesium dependent beta isoform antibody; Protein phosphatase 2C beta isoform antibody; Protein phosphatase 2C isoform beta antibody; Protein phosphatase 2C like protein antibody; Protein phosphatase, Mg2+/Mn2+ dependent, 1B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PPM1B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
  • 基因功能参考文献：
    1. Results indicate that protein phosphatase 1B (PPM1B) negatively regulates cancer cell motility and invasiveness through dephosphorylating Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1). PMID: 29307615
    2. PPM1B plays a negative role in the activation of the p38-RB1-E2F1 pathway and that targeting PPM1B could be useful in certain types of cancer by stimulating chemotherapy-induced cell death. PMID: 29654756
    3. This study has identified PPM1B and miR-186 as potential diagnostic markers in bladder cancer. Promotion of PPM1B and suppression of miR-186 may offer effective therapeutic strategies in the treatment of bladder cancer. PMID: 26494000
    4. PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. PMID: 25631048
    5. Results identify PPM1B as a critical regulator of both p38 MAPK-dependent and independent senescence pathways during normal cellular aging process. PMID: 24674756
    6. Cadmium reversed PPM1A-induced cell cycle arrest and cadmium insensitive PPM1A mutant rescued cadmium induced cell death. PMID: 23903585
    7. Protein kinase A activates NF-kappaB-mediated transcription by destabilization of PP2Cbeta. PMID: 23756813
    8. PPM1B functions as a TBK1 phosphatase dephosphorylates TBK1 at serine 172 and terminates TBK1-mediated IRF3 activation and IFNbeta gene expression. PMID: 22750291
    9. Studies show that Ppm1b plays a multilayered role in regulating the availability and optimal activity of the EKLF protein in erythroid cells. PMID: 22393050
    10. results implicate a novel and important role for PP2Cbetal in regulating hPXR activity and CYP3A4 expression by inhibiting or desensitizing signaling pathways that negatively regulate the function of pregnane X receptor in liver cells PMID: 20538721
    11. PP2Cbeta down-regulates cytokine-induced NF-kappaB activation by altering IKK activity. PMID: 14585847
    12. Protein phosphatase 1B is mediated dephosphorylation and inactivation of I-kappa B kinase as well as the termination of the Tumor Necrosis Factor-alpha-induced NF-kappaappaB activation. PMID: 18930133

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  • 亚细胞定位：
    Cytoplasm, cytosol. Membrane; Lipid-anchor.
  • 蛋白家族：
    PP2C family
  • 组织特异性：
    Highly expressed in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 9276

    OMIM: 603770

    KEGG: hsa:5495

    STRING: 9606.ENSP00000282412

    UniGene: Hs.416769