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PPM1A Antibody

  • 货号：
    CSB-PA018489GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P35813
  • 基因名：
  • 别名：
    Protein phosphatase 2C isoform alpha antibody; EC 3.1.3.16 antibody; FLJ42306 antibody; IA antibody; MGC9201 antibody; Mpp alpha antibody; PP2C alpha antibody; PP2C-alpha antibody; PP2CA antibody; PP2Calpha antibody; PPM 1A antibody; PPM1A antibody; PPM1A_HUMAN antibody; PPPM1A antibody; Protein phosphatase 1A (formerly 2C) magnesium dependent alpha isoform antibody; Protein phosphatase 1A antibody; Protein phosphatase 1A magnesium dependent alpha antibody; Protein phosphatase 2C alpha antibody; Protein phosphatase 2C alpha isoform antibody; Protein phosphatase 2C isoform alpha antibody; Protein phosphatase IA antibody; Protein phosphatase, Mg2+/Mn2+ dependent, 1A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PPM1A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
  • 基因功能参考文献：
    1. PPM1A as a negative threshold regulator of M1-type monocyte-to-macrophage differentiation. PMID: 29343725
    2. Here the s establish PPM1A as a checkpoint target used by Mycobacterium tuberculosis to suppress macrophage apoptosis. Overproduction of PPM1A suppressed apoptosis of Mycobacterium tuberculosis-infected macrophages by a mechanism that involves inactivation of the c-Jun N-terminal kinase (JNK). PMID: 28176854
    3. Present study suggests that HBx-induced degradation of PPM1a is a novel mechanism for over-activation of TGF-beta pathway in HCC development. PMID: 27121309
    4. Findings show that HCV infection and replication decreased PPM1A abundance, mediated by NS3, in hepatoma cells. Compared to normal liver tissues, the expression of PPM1A was significantly decreased in the HCC tumor tissues and adjacent non-tumor tissues through its regulation by NS3 which promotes its ubiquitination and proteasomal degradation. PMID: 28283039
    5. These data suggest that PPM1A, which had previously been shown to play a role in the antiviral response to Herpes Simplex virus infection, also governs the antibacterial response of macrophages to bacteria, or at least to Mycobacterium tuberculosis infection PMID: 27004401
    6. establish PPM1A as a novel repressor of the SMAD3 pathway in renal fibrosis PMID: 27328942
    7. Report a tumor-suppressive function of PPM1A and an independent relationship to Smad4 in pancreatic ductal adenocarcinoma. PMID: 27195906
    8. hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha between the active and inactive states PMID: 28481111
    9. In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A; P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin. PMID: 27301936
    10. findings demonstrate a novel regulatory circuit in which STING and TBK1 reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 PMID: 25815785
    11. The TGF-beta/Smad signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A upregulation. PMID: 24901250
    12. Loss of PPM1A is associated with the development of tumor invasion in bladder cancer patients. PMID: 25026293
    13. PPM1A is a RelA phosphatase that regulates NF-kappaB activity and that PPM1A has tumor suppressor-like activity. PMID: 23812431
    14. a nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A. PMID: 23779087
    15. phosphatase activity toward phosphopeptide substrates by PP2Calpha and Wip1 requires the binding of a Mg(2)+ ion to the low-affinity site. PMID: 23906386
    16. PPM1A negatively regulates ERK by directly dephosphorylating its pThr202 position early in epidermal growth factor stimulation. Additional kinetic studies reveal that key residues participate in phospho-ERK recognition by PPM1A. PMID: 23560844
    17. Studies indicate that phosphatase PPM1G is a component of the spliceosome and binds to protein YB-1 to affect alternative splicing. PMID: 22519956
    18. PPM1A inhibits HIV-1 infection and gene expression. PPM1A depletion in resting CD4+ T cells increases HIV-1 gene expression. PMID: 22727189
    19. High expression of LMP2 and low expression of PPM1A might play an important role in the motility and invasiveness of trophoblast cells and malignant transformation of hydatidiform mole. PMID: 22041443
    20. This work demonstrates that PPM1A/PP2Calpha, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFbeta signaling. PMID: 16751101
    21. PPM1A plays an important role in controlling BMP signaling through catalyzing Smad1 dephosphorylation PMID: 16931515
    22. Aberrant location of expression/staining intensity of PTEN, PPM1A and P-Smad2 in hepatocellular carcinoma may impact disease progression. PMID: 17729405
    23. PTEN abrogates TGF-beta-induced Smad2/3 phosphorylation. This study establishes a novel role for nuclear PTEN in the stabilization of PPM1A. PMID: 18482992
    24. Overexpression of PPM1A and the related PPM1B greatly reduced Cdk9 T-loop phosphorylation PMID: 18829461
    25. Protein phosphatase 1A is essential to terminate I-kappa B Kinase-mediated NF-kappaappaB activation through binding to the activated form of I-kappa B Kinase and dephosphorylating I-kappa B Kinase at the conserved residues Ser177 and Ser181. PMID: 18930133
    26. The present data indicate that PPM1A plays a critical role in the regulation of normal placentation by inhibiting trophoblast migration and invasion. PMID: 19404668

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  • 亚细胞定位：
    Nucleus. Cytoplasm, cytosol. Membrane; Lipid-anchor.
  • 蛋白家族：
    PP2C family
  • 数据库链接：

    HGNC: 9275

    OMIM: 606108

    KEGG: hsa:5494

    STRING: 9606.ENSP00000327255

    UniGene: Hs.130036