PPID Antibody

1. Binding of signal transducer and activator of transcription 3 (STAT3) to cyclophilin D (CypD) was important for reducing mitochondrial reactive oxygen species (ROS) production after oxidative stress. PMID: 28351946
2. Data show that cyclophilin 40 (CyP40) interacts with and dissolves amyloids forming proteins tau and alpha-synuclein aggregates. PMID: 28654636
3. This review discusses previous studies to provide comprehensive information on the physiological role of cyclophilin D as well as PTP opening in the cell that can be taken into consideration for the development of new PTP inhibitors. [review] PMID: 28378042
4. The influx of unfolded p53 into the mitochondrial matrix in response to oxidative stress indirectly activates the normally inhibited CypD by displacing it from Trap1 complexes. This activates CypD's isomerase activity. Liberated CypD then isomerizes multiple proteins including p53 (causing p53 aggregation) and the structural components of the mPTP pore, inducing pore opening. PMID: 27515399
5. The present study is to investigate the role of CypD in regulating the mitochondrial dynamics relevant to oxidative stress induced neuron dysfunctions. PMID: 27993675
6. CyPD regulates mitochondrial metabolism, and likely cell survival, by promoting more efficient electrons flow through the respiratory chain via increased supercomplex formation PMID: 27916505
7. cyclophilin D may modify mitochondrial features by inducing the translocation of molecules to the mitochondria through the mechanism associated with cellular energy metabolism PMID: 27864141
8. The thermodynamics of binding of Cyp-40 to Hsp90 shows remarkable temperature sensitivity in the physiological temperature range. PMID: 26330616
9. cyclophilin-D protein could increase oxidative stress and cause endothelial cell injury and apoptosis. cyclophilin-D protein is the key factor in reactive oxygen species-induced mitochondrial damage, leading to apoptosis of endothelial cells. PMID: 25966197
10. Results show that CypD interacts with SPG7 and VDAC to form the mitochondrial permeability transition pore complex (PTP)and its CsA-binding region is necessary for PTP formation. PMID: 26387735
11. molecular determinants necessary for Cyclophilin D activity regulation and binding to proposed pore constituents thereby regulating the mitochondrial permeability transition pore. PMID: 25445707
12. Cyp-D silencing down-regulated mitochondrial transcripts initiated from the heavy strand promoter 2 [i.e., NADH dehydrogenase 1 (ND1) by 11-fold; cytochrome oxidase 1 (COX1) by 4-fold; and ATP synthase subunit 6 (ATP6) by 6.5-fold. PMID: 25837584
13. Cyp40 binds to C2I in vitro and in intact cells, it also interacts with the enzyme components of iota toxin and CDT, suggesting a common principle for this toxin family. PMID: 25058685
14. The Photorhabdus toxins TccC3 and TccC5 interacted with Hsp90, FKBP51, Cyp40 and CypA, suggesting a role of these host cell factors in translocation and/or refolding of the ADP-ribosyltransferases. PMID: 24138221
15. The p53/Cyp-D mitochondrial complexation was prevented by CsA or Cyp-D silencing. PMID: 24343341
16. In summary, the results of the present study provide mechanistic evidence that both apoptosis and programmed necrosis attribute to berberine's cytotoxicity in prostate cancer cells. PMID: 24946211
17. cisplatin-induced non-apoptotic death requires mitochondria Cyp-D-p53 signaling in pancreatic cancer cells PMID: 23845906
18. CypD directs mitochondria-to-nuclei inflammatory gene expression in normal and tumor cells PMID: 23303179
19. These results suggest Cyp-D's critical role in UVB/oxidative stress-induced skin cell death. PMID: 22892127
20. this is the first report establishing an important role for Cyp40 in lymphoma. PMID: 22681779
21. Human coronavirus-induced neuronal programmed cell death required cyclophilin d but not caspase 3 caspase 9 activities. PMID: 22013052
22. adult viable human brain and liver mitochondria possess an active CypD-sensitive mitochondrial permeability transition PMID: 21121808
23. Data show that show that the molecular chaperone heat shock protein 60 (Hsp60) directly associates with cyclophilin D (CypD). PMID: 20978188
24. Data show that disruption of FKBP51 and Cyp40 in AI C4-2 cells caused only a small reduction in proliferation. PMID: 20023700
25. cyclophilin D suppresses apoptotic cell death via a mitochondrial hexokinase II-dependent mechanism in cancer cells PMID: 16551620
26. CyP40 chaperone function then, is localized within the linker that forms a binding cleft with potential to accommodate non-native substrates PMID: 16650407
27. Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution, using a K133I mutant of human CypD PMID: 18076075
28. CyP40 is found in the cell nucleus after 3-methylchloranthrene treatment and appears to promote the dioxin response element binding form of the AhR/Arnt heterodimer. PMID: 18708059
29. CypD-mediated mitochondrial permeability transition pore is directly linked to the cellular and synaptic perturbations observed in the pathogenesis of Alzheimer's disease. PMID: 18806802
30. Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect PMID: 19228691
31. Cyclophilin D may play a role as a redox sensor in mitochondria of mammalian cells transmitting information on the redox environment to target proteins. PMID: 19735641

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HGNC: 9257

OMIM: 601753

KEGG: hsa:5481

STRING: 9606.ENSP00000303754

UniGene: Hs.183958