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PPFIA1 Antibody

  • 货号：
    CSB-PA618760DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA618760DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA618760DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPFIA1 Polyclonal antibody
  • Uniprot No.：
    Q13136
  • 基因名：
    PPFIA1
  • 别名：
    FLJ42630 antibody; HGNC:9245 antibody; LAR interacting protein 1 antibody; LAR-interacting protein 1 antibody; LIP 1 antibody; LIP-1 antibody; LIP.1 antibody; LIP1 antibody; LIPA1_HUMAN antibody; Liprin alpha 1 antibody; LIPRIN antibody; Liprin-alpha-1 antibody; MGC26800 antibody; PPFIA 1 antibody; PPFIA1 antibody; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 1 antibody; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1 antibody; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1 antibody; PTPRF interacting protein alpha 1 antibody; PTPRF-interacting protein alpha-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Liprin-alpha-1 protein (660-800AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
  • 基因功能参考文献：
    1. The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility. PMID: 29348417
    2. This study shows that PPFIA1 is required for FN polymerization-dependent vascular morphogenesis, both in vitro and in the developing zebrafish embryo. PMID: 27876801
    3. Based on these findings, we infer that high PPFIA1 expression might be an independent prognostic indicator of increased metastatic relapse risk in patients with estrogen receptor+/N- breast cancer, but not in estrogen receptor+/N+ or estrogen receptor- patients. PMID: 28720060
    4. The human tumor cell line MDA-MB-231 expresses liprin-alpha 1 and is able to promote the formation of metastasis in mice. PMID: 26663347
    5. results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity. PMID: 25492966
    6. Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge PMID: 24982445
    7. PPFIA1 was frequently co-amplified with the Cyclin D1 gene in oral carcinomas and could present a biomarker as well as a novel target for specific gene therapy. PMID: 23453270
    8. PPFIA1 as a potential functional candidate acute lung injury risk gene PMID: 22295056
    9. The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions PMID: 22072677
    10. These results suggest that an increased expression of Liprin-alpha1 in the brain may be associated with human Intractable epilepsy . PMID: 21157931
    11. Data show that increased levels of liprin-alpha1 affected the localization of inactive, low-affinity integrins, while increasing the average size of beta1 integrin-positive focal adhesions. PMID: 20096687
    12. Amplification of both PPFIA1 and CCND1 were significantly associated with high-grade breast cancer phenotype but were unrelated to tumor stage or nodal stage PMID: 19787783
    13. the interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones PMID: 12923177
    14. liprin binds to ATP-agarose, challenged by free ATP, not by free GTP. Liprin LH region mutations inhibit liprin phosphorylation stabilized association of liprin with ATP-agarose. Suggests that liprin autophosphorylation regulates its association with LAR. PMID: 16313174
    15. regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996
    16. Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, is associated with head and neck squamous cell carcinoma PMID: 18196592
    17. Liprin is an essential regulator of cell motility that contributes to the effectiveness of cell-edge protrusion. PMID: 19690048

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  • 亚细胞定位：
    Cytoplasm. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus.
  • 蛋白家族：
    Liprin family, Liprin-alpha subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 9245

    OMIM: 611054

    KEGG: hsa:8500

    STRING: 9606.ENSP00000253925

    UniGene: Hs.530749