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POU4F1 Antibody

  • 货号：
    CSB-PA030134
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q01851
  • 基因名：
    POU4F1
  • 别名：
    Brain specific homeobox/POU domain protein 3A antibody; Brain-3A antibody; Brain-specific homeobox/POU domain protein 3A antibody; Brn 3.0 antibody; BRN 3A antibody; Brn-3A antibody; Brn3 antibody; BRN3A antibody; class 4 antibody; FLJ13449 antibody; Homeobox/POU domain protein RDC 1 antibody; Homeobox/POU domain protein RDC-1 antibody; Homeobox/POU domain protein RDC1 antibody; Oct T1 antibody; Oct-T1 antibody; OctT1 antibody; PO4F1_HUMAN antibody; POU class 4 homeobox 1 antibody; POU domain antibody; POU Domain Class 4 Transcription Factor 1 antibody; Pou4f1 antibody; RDC 1 antibody; RDC1 antibody; transcription factor 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Brn-3a.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.; Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have antiapoptotic effect on neuronal cells.
  • 基因功能参考文献：
    1. We report a case of a nine-year-old male who presented with facial nerve stimulation four years after cochlear implantation. A dilated internal auditory meatus was revealed. Genetic analysis demonstrated X-linked deafness type 2 (DFNX2) caused by a novel c.769C T nucleotide change in the POU domain, class 3, transcription factor 4 gene PMID: 27863625
    2. Brn3a cooperates with activated RAS/RAF signalling by reducing oncogene-induced senescence in melanocytic tumourigenesis. PMID: 23666755
    3. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. PMID: 22930747
    4. PoU4F1 is highly expressed in t(8;21) samples, with AML/ETO appearning to promote some BRN3A expression PMID: 22064348
    5. BRN3A possesses anti-apoptotic property, and considering the above results, it may be regarded as the key component in promoting tumorigenic growth in the uterine cervical cells. PMID: 21928122
    6. Ewing sarcoma induce expression of neuronal markers such as BRN3A showing that the function of those same markers may be restricted or controlled in an sarcoma-dependent manner. PMID: 20348952
    7. Dysregulation of POU4F1 is associated with t(8;21) acute myeloid leukemia. PMID: 20376082
    8. genomic organization of the Brn-3a locus and the mechanisms that control the expression of two different proteins from one genomic locus PMID: 12427558
    9. Measurement of Brn-3a levels in smears can be used to detect a significant proportion of cervical lesions that were missed by Pap smear. PMID: 12893201
    10. These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening. PMID: 12911730
    11. oncogenic rearrangement of EWS to produce EWS/Fli-1 may enhance the antiapoptotic effect of Brn-3a and inhibit its ability to promote neuronal differentiation. PMID: 15021903
    12. Hsp27 expression and cell survival are regulated by the POU transcription factor Brn3a PMID: 15272315
    13. Brn-3a has a role in differential regulation of different human papilloma virus variants PMID: 16247485
    14. Upregulation of Brn-3a is associated with prostate cancer PMID: 16276351

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    POU transcription factor family, Class-4 subfamily
  • 组织特异性：
    Expressed in the brain and the retina. Present in the developing brain, spinal cord and eye.
  • 数据库链接：

    HGNC: 9218

    OMIM: 601632

    KEGG: hsa:5457

    STRING: 9606.ENSP00000366413

    UniGene: Hs.654522