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POU3F1 Antibody

  • 货号：
    CSB-PA003510
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using Oct-6 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q03052
  • 基因名：
    POU3F1
  • 别名：
    class 3 antibody; Oct-6 antibody; OCT6 antibody; Octamer-binding protein 6 antibody; Octamer-binding transcription factor 6 antibody; OTF-6 antibody; OTF6 antibody; PO3F1_HUMAN antibody; POU class 3 homeobox 1 antibody; POU domain antibody; POU domain class 3 transcription factor 1 antibody; POU domain transcription factor SCIP antibody; pou3f1 antibody; SCIP antibody; transcription factor 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human 40822.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. Acts as a transcriptional repressor of myelin-specific genes.
  • 基因功能参考文献：
    1. Combined high OATP1A2/high OCT6 may be a potential predictor of response to anthracycline/taxane-based chemotherapy in breast cancer PMID: 24671357
    2. CpG island hypermethylation contributes to down-regulation of Oct-6 mRNA expression in hepatocellular carcinoma. PMID: 21448695
    3. Our results suggest that Tst-1 and Skn-1a regulate expression of MMPs in keratinocytes and effect both the expression and activation of these proteolytic enzymes. PMID: 17195013
    4. Strict control of Pou3f1 transgene expression is critical to proper myelination, and factors responsible for Pouf31 downregulation during myelination may play important roles in the development of peripheral neuropathies. PMID: 17959798
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    POU transcription factor family, Class-3 subfamily
  • 组织特异性：
    Expressed in embryonal stem cells and in the developing brain.
  • 数据库链接：

    HGNC: 9214

    OMIM: 602479

    KEGG: hsa:5453

    STRING: 9606.ENSP00000362103

    UniGene: Hs.1837